Stover Cordula M, McDonald John, Byrne Simon, Lambert David G, Thompson Jonathan P
Department of Infection, Immunity and Inflammation, College of Medicine, Biological Sciences and Psychology, University of Leicester , Leicester , UK.
Department of Cardiovascular Sciences, Division of Anaesthesia, Critical Care and Pain Management, University of Leicester , Leicester , UK.
Front Immunol. 2015 Feb 2;6:24. doi: 10.3389/fimmu.2015.00024. eCollection 2015.
Properdin is a normal serum protein that increases the production of complement activation products by binding C3b integral to convertase complexes and amplifying their activity at the site of activation. Thereby, it not only can aid in the resolution of infection but also contribute to tissue damage. In human sepsis, circulating complement C3 concentrations are decreased, though C3 is described as a positive acute phase reactant. However, properdin levels in human sepsis have not been reported. In this study, serum from 81 critically ill patients (predominately abdominal and respiratory sepsis) were analyzed for properdin levels at defined points of their stay in the intensive care unit (ICU) and compared with 61 age and sex-matched healthy volunteers. Properdin concentrations were significantly decreased in patients with sepsis on admission to ICU, but increased after clinical recovery to exceed levels observed in healthy volunteers. Properdin concentrations at ICU admission were decreased in non-survivors of sepsis compared to survivors, but this did not correlate with APACHE II score. However, pathologically low properdin levels (<7 μg/ml) were related to increased duration of treatment.
备解素是一种正常血清蛋白，它通过结合转化酶复合物中的C3b来增加补体激活产物的生成，并在激活部位放大其活性。因此，它不仅有助于感染的消退，还会导致组织损伤。在人类脓毒症中，循环补体C3浓度降低，尽管C3被描述为一种阳性急性期反应物。然而，尚未有关于人类脓毒症中备解素水平的报道。在本研究中，分析了81例危重症患者（主要为腹部和呼吸道脓毒症）在重症监护病房（ICU）住院期间特定时间点的血清备解素水平，并与61名年龄和性别匹配的健康志愿者进行比较。脓毒症患者在入住ICU时备解素浓度显著降低，但临床恢复后升高，超过了健康志愿者中观察到的水平。与幸存者相比，脓毒症非幸存者入住ICU时的备解素浓度降低，但这与急性生理学及慢性健康状况评分系统（APACHE II）评分无关。然而，病理状态下低备解素水平（<7μg/ml）与治疗时间延长有关。
