Sakuma S, Maekawa K, Ishikawa H
Department of Pediatrics, Jikei University School of Medicine, Tokyo, Japan.
Brain Res. 1989 Jul 31;493(2):402-6. doi: 10.1016/0006-8993(89)91179-7.
Immunoreactivities of somatostatin and growth hormone-releasing factor (GRF) in the hypothalamus of spontaneous dwarf rats (SDRs, gene symbol; dr), which show isolated growth hormone (GH) deficiency, and normal rats were studied with an avidin-biotin complex (ABC) immunohistochemical method. Somatostatin and GRF immunoreactivities were observed in the median eminence and each afferent nucleus with no difference between these animals. The observation suggests that the etiology of the GH deficiency lies in GH cells themselves and is not hypothalamic in origin. This observation indicates that the SDR is a new model animal for type I dwarfism.
采用抗生物素蛋白-生物素复合物（ABC）免疫组织化学方法，研究了表现为孤立性生长激素（GH）缺乏的自发性侏儒大鼠（SDRs，基因符号：dr）和正常大鼠下丘脑内生长抑素和生长激素释放因子（GRF）的免疫反应性。在正中隆起和每个传入核中均观察到生长抑素和GRF免疫反应性，这些动物之间无差异。该观察结果表明，GH缺乏的病因在于GH细胞自身，而非下丘脑起源。这一观察结果表明，SDR是I型侏儒症的一种新的模型动物。
