Tsochandaridis Marthe, Nasca Laurent, Toga Caroline, Levy-Mozziconacci Annie
Assistance Publique-Hôpitaux de Marseille, Laboratoire de Biochimie et Biologie Moléculaire, Unité de Biologie Materno-Fœtale, Hôpital Nord, Chemin des Bourrely, 13015 Marseille, France.
Assistance Publique-Hôpitaux de Marseille, Centre Pluridisciplinaire de Diagnostic Prénatal, Hôpital Nord, Chemin des Bourrely, 13015 Marseille, France.
Biomed Res Int. 2015;2015:294954. doi: 10.1155/2015/294954. Epub 2015 Jan 29.
Predicting pregnancy complications is a major topic for clinicians and biologists for maternal and fetal monitoring. Noninvasive biomarkers in maternal blood such as circulating microRNAs (miRNAs) are promising molecules to predict pregnancy disorders. miRNAs are noncoding short RNAs that regulate mRNA expression by repressing the translation or cleaving the transcript. miRNAs are released to the extracellular systemic circulation via exosomes. The discovery of plasma- or serum-derived miRNAs and of free-circulating exosomes that contain miRNAs provides useful information about the physiological or pathophysiological roles of the miRNAs. Specific placental miRNAs are present in maternal plasma in different ways depending on whether the pregnancy is normal or pathological or if there is no pregnancy. This paper focuses on placental miRNAs and extracellular miRNAs to the placenta whose misregulation could lead to pregnancy complications.
预测妊娠并发症是临床医生和生物学家进行母婴监测的一个主要课题。母体血液中的非侵入性生物标志物，如循环微小RNA（miRNA），是预测妊娠疾病的有前景的分子。miRNA是通过抑制翻译或切割转录本来调节mRNA表达的非编码短RNA。miRNA通过外泌体释放到细胞外全身循环中。血浆或血清来源的miRNA以及含有miRNA的游离循环外泌体的发现，为miRNA的生理或病理生理作用提供了有用信息。特定的胎盘miRNA以不同方式存在于母体血浆中，这取决于妊娠是否正常、是否为病理性妊娠或是否未妊娠。本文重点关注胎盘miRNA和胎盘外的细胞外miRNA，其失调可能导致妊娠并发症。
