Hao Meijun, Wang Xiaojun, Du Jingpei, Liu Lifeng, Jiao Yanmei, Wu Hao, Zheng Jiasheng, Li Wei
Intervention Therapy Center of Liver Diseases, Beijing You'an Hospital, Capital Medical University, Beijing, China.
J Infect Dev Ctries. 2015 Feb 19;9(2):190-6. doi: 10.3855/jidc.5255.
Varicella is a highly contagious disease. Epidemics of varicella are seen every year globally and present a threat to public health, especially in China and other developing countries.
Clinical and laboratory findings of 865 varicella patients admitted to Beijing You'an Hospital, China, between January 2011 and December 2013 were collected and analyzed. Patients with isolated complication were grouped as SI (skin infection, n = 132) and LD (liver damage, n = 89). Two hundred and one patients without complications were grouped as control (mild group). Levels of T-cell subtypes and eight serum cytokines and were also tested. Levels of IFNg and IL-6 were monitored prospectively in another 12 grouped patients.
SI was complicated in 21.7% (188/865) of varicella cases, and LD was complicated in 16.8% (145/865). The rates of SI and LD in varicella patients increased rapidly in the past three years. No laboratory findings were associated with SI or LD (all p > 0.05). IL-6 and IFNg levels were correlated with amniotic membrane extract (AME) (p = 0.044 and p = 0.038). Their levels peaked at day 1 of admission, and then started to decline.
The incidence of serious complications has become more common in recent years. IL-6 and IFNg may possibly be used as early serum markers for identifying patients at risk of developing complications such as skin infections in varicella.
水痘是一种高度传染性疾病。全球每年都会出现水痘疫情，对公众健康构成威胁，在中国和其他发展中国家尤为如此。
收集并分析了2011年1月至2013年12月期间在中国北京佑安医院住院的865例水痘患者的临床和实验室检查结果。将有孤立并发症的患者分为SI组（皮肤感染，n = 132）和LD组（肝损伤，n = 89）。将201例无并发症的患者分为对照组（轻症组）。还检测了T细胞亚群水平和八种血清细胞因子。对另外12例分组患者前瞻性监测IFNg和IL-6水平。
水痘病例中21.7%（188/865）并发SI，16.8%（145/865）并发LD。水痘患者的SI和LD发生率在过去三年中迅速上升。没有实验室检查结果与SI或LD相关（所有p>0.05）。IL-6和IFNg水平与羊膜提取物（AME）相关（p = 0.044和p = 0.038）。它们的水平在入院第1天达到峰值，然后开始下降。
近年来严重并发症的发生率变得更加常见。IL-6和IFNg可能可用作早期血清标志物，以识别水痘患者发生皮肤感染等并发症风险。
