Haber James E
Rosenstiel Basic Medical Sciences Research Center and Department of Biology, Brandeis University, Waltham, MA 02454, USA.
Mol Cell. 2015 Feb 19;57(4):577-581. doi: 10.1016/j.molcel.2015.02.004.
Double-strand breaks (DSBs) threaten chromosome integrity. The most accurate repair of DSBs is by homologous recombination (HR), catalyzed by recombination proteins such as Rad51. Three papers in this issue of Molecular Cell (Fasching et al., 2015; Kaur et al., 2015; Tang et al., 2015) now reveal the role of three of these proteins in budding yeast: Sgs1 (BLM homolog), Top3 (TOPIIIα homolog), and Rmi1. They demonstrate several steps where all three proteins act together, and find additional functions of the Top3-Rmi1 subcomplex that are critical for the completion of meiosis.
双链断裂（DSB）会威胁染色体的完整性。双链断裂最准确的修复方式是通过同源重组（HR），由诸如Rad51等重组蛋白催化。本期《分子细胞》杂志上的三篇论文（Fasching等人，2015年；Kaur等人，2015年；Tang等人，2015年）现在揭示了其中三种蛋白在芽殖酵母中的作用：Sgs1（BLM同源物）、Top3（TOPIIIα同源物）和Rmi1。它们展示了这三种蛋白共同发挥作用的几个步骤，并发现了Top3-Rmi1亚复合物对于减数分裂完成至关重要的其他功能。
