巴西百日咳博德特氏菌疫苗株的全基因组序列
Whole-Genome Sequence of a Bordetella pertussis Brazilian Vaccine Strain.
作者信息
Akamatsu M A, Nishiyama M Y, Morone M, Oliveira U C, Bezerra M F B, Sakauchi M A, Raw I, Junqueira de Azevedo I L M, Kitajima J P, Carvalho E, Ho P L
机构信息
Divisão de Desenvolvimento Tecnológico e Produção, Instituto Butantan, São Paulo, Brazil.
Laboratório Especial de Toxinologia Aplicada, Centro de Toxinas, Resposta Imune e Sinalização Celular (CeTICS), Instituto Butantan, São Paulo, Brazil.
出版信息
Genome Announc. 2015 Feb 19;3(1):e01570-14. doi: 10.1128/genomeA.01570-14.
Abstract
Despite the reduction in incidence after vaccination, pertussis disease is still considered a public health problem worldwide, mainly due to recent and potential new outbreaks. We report here the complete genome of the Bordetella pertussis Butantan strain used in the Brazilian National Immunization Program as a whole-cell pertussis antigen to compose vaccines such as DTwP (diphtheria, tetanus, and whole-cell pertussis).
摘要
尽管接种疫苗后发病率有所下降，但百日咳疾病在全球范围内仍被视为一个公共卫生问题，主要是由于近期和潜在的新疫情爆发。我们在此报告巴西国家免疫计划中用作全细胞百日咳抗原以制备如白百破疫苗（DTwP，即白喉、破伤风和全细胞百日咳疫苗）的百日咳博德特氏菌布坦坦菌株的完整基因组。
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