德国路德维希斯鲁特中小学百日咳疫情表明了免疫力下降的作用。
Pertussis outbreak in primary and secondary schools in Ludwigslust, Germany demonstrating the role of waning immunity.
作者信息
Sin Muna Abu, Zenke Rosemarie, Rönckendorf Rita, Littmann Martina, Jorgensen Pernille, Hellenbrand Wiebke
机构信息
Field Epidemiology Training Program, Robert Koch Institute, Berlin, Germany.
出版信息
Pediatr Infect Dis J. 2009 Mar;28(3):242-4. doi: 10.1097/INF.0b013e31818a5d69.
A pertussis outbreak primarily affecting school-age children in Ludwigslust, Germany, was investigated in 2006 to estimate attack rates and relative risk of pertussis according to time since last vaccination, after a complete primary course. Results suggested waning immunity beginning approximately 5 years after the last dose of pertussis vaccination. Most cases could have been prevented by earlier booster vaccination.
2006年，对德国路德维希斯卢斯特市一场主要影响学龄儿童的百日咳疫情进行了调查，以根据上次全程基础免疫接种后的时间估算百日咳的发病率和相对风险。结果表明，在最后一剂百日咳疫苗接种约5年后，免疫力开始下降。大多数病例本可通过更早接种加强疫苗而得到预防。
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