Keck P E, Sebastianelli J, Pope H G, McElroy S L
Mailman Research Center, McLean Hospital, Belmont, Mass 02178.
J Clin Psychiatry. 1989 Sep;50(9):352-5.
Neuroleptic malignant syndrome, a dangerous complication of antipsychotic drugs, has recently been recognized to occur more commonly than previously thought. However, the frequency of this syndrome has been assessed primarily in academic centers, and these reports may not adequately reflect its frequency in other settings. In a 2-year retrospective assessment of 551 neuroleptic-treated patients in a state psychiatric hospital, the authors diagnosed neuroleptic malignant syndrome in 5 cases (0.9%) using previously defined operational criteria. This observation suggests that the syndrome is probably as common in state facilities as in other institutions.
抗精神病药物的危险并发症——神经阻滞剂恶性综合征，最近被认为比之前想象的更为常见。然而，该综合征的发生率主要是在学术中心进行评估的，这些报告可能无法充分反映其在其他环境中的发生率。在一家州立精神病医院对551名接受抗精神病药物治疗的患者进行的为期2年的回顾性评估中，作者使用先前定义的操作标准诊断出5例（0.9%）神经阻滞剂恶性综合征。这一观察结果表明，该综合征在州立机构中的发生率可能与在其他机构中一样普遍。
