Josephs Keith A
Behavioural Neurology and Movement Disorders, Mayo Clinic, Rochester, MN, 55905, USA,
J Neurol. 2015 Mar;262(3):783-8. doi: 10.1007/s00415-015-7682-y. Epub 2015 Feb 21.
It has been approximately 50 years since neurologists were introduced to the entities, "progressive supranuclear palsy" and "corticobasal degeneration". Since the two seminal publications, there have been significant advancements in our understanding of these two neurodegenerative diseases, particularly the fact that both are associated with tau. Recent advances over the past 3 years that are notable to the field are discussed in this review that covers clinical diagnosis, pathological features, neuroimaging and CSF biomarkers, genetic associations and clinical trials related to progressive supranuclear palsy and corticobasal degeneration.
自神经科医生首次接触到“进行性核上性麻痹”和“皮质基底节变性”这两种病症以来，已经过去了大约50年。自这两篇具有开创性的论文发表以来，我们对这两种神经退行性疾病的认识有了重大进展，尤其是认识到这两种疾病都与tau蛋白有关。本综述讨论了过去3年该领域值得关注的最新进展，内容涵盖进行性核上性麻痹和皮质基底节变性的临床诊断、病理特征、神经影像学、脑脊液生物标志物、基因关联以及临床试验。
