[青光眼病程中的结构改变]
[Structural alterations during the course of glaucoma disease].
作者信息
Mardin C Y, Schlötzer-Schrehardt U
机构信息
Universitätsaugenklinik Erlangen, Schwabachanlage 6, 91054, Erlangen, Deutschland,
出版信息
Ophthalmologe. 2015 May;112(5):410-7. doi: 10.1007/s00347-014-3152-7.
BACKGROUND
Structural changes in the course of glaucoma disease affect the trabecular meshwork and ciliary body in addition to the optic disc as the primary site of glaucoma damage.
OBJECTIVES
Latest results from experimental studies, animal models and measurements in human eyes are presented and discussed.
RESULTS
The presenting scenario is complex with age, biochemical and mechanical stress factors leading to subsequent, irreversible tissue change in the trabecular meshwork and cribriform plate of the optic nerve, resulting in neuronal tissue loss.
CONCLUSION
Knowledge of these changes will be the key for future glaucoma therapies.
背景
青光眼病程中的结构变化除了影响作为青光眼损害主要部位的视盘外，还会影响小梁网和睫状体。
目的
展示并讨论来自实验研究、动物模型及人眼测量的最新结果。
结果
目前的情况很复杂，年龄、生化和机械应激因素会导致小梁网和视神经筛板随后发生不可逆的组织变化，从而导致神经元组织丧失。
结论
了解这些变化将是未来青光眼治疗的关键。
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