Herregodts P, Bruyland M, De Keyser J, Solheid C, Michotte Y, Ebinger G
Department of Neurology, University Hospital, Brussels, Belgium.
J Neurol Sci. 1989 Aug;92(1):101-16. doi: 10.1016/0022-510x(89)90179-2.
Norepinephrine, epinephrine, dopamine, serotonin and their major metabolites were measured in 20 regions of the left hemisphere in 4 presenile familial cases of Alzheimer-type dementia and 4 sporadic senile cases. Both groups were compared to values in normal brains obtained in our laboratory. Quantitative determination of the monoamines was performed by HPLC with electrochemical detection. The clinical diagnosis of Alzheimer-type dementia was confirmed by histological examination of the right hemisphere and brain stem. The serotonergic system was dramatically affected in the familial cases with very low or undetectable serotonin concentrations in most cortical and subcortical areas studied and an important cell loss in the nucleus raphe dorsalis, origin of the main ascending serotonergic system. In the senile demented patients the serotonergic deficit is less important but still clearly present. The noradrenergic, adrenergic and dopaminergic systems were less affected by the disease process in senile sporadic as well as in the presenile familial type of Alzheimer's disease.
在4例早老性家族性阿尔茨海默病型痴呆患者和4例散发性老年性痴呆患者的左半球20个区域中，对去甲肾上腺素、肾上腺素、多巴胺、血清素及其主要代谢产物进行了测量。将两组与我们实验室获得的正常大脑中的值进行比较。采用高效液相色谱-电化学检测法对单胺类物质进行定量测定。通过对右半球和脑干的组织学检查证实了阿尔茨海默病型痴呆的临床诊断。在家族性病例中，血清素能系统受到显著影响，在大多数研究的皮质和皮质下区域，血清素浓度非常低或无法检测到，并且主要上行血清素能系统的起源——中缝背核出现了重要的细胞丢失。在老年性痴呆患者中，血清素能缺陷虽不那么严重，但仍明显存在。在老年性散发性以及早老性家族性阿尔茨海默病中，去甲肾上腺素能、肾上腺素能和多巴胺能系统受疾病进程的影响较小。
