Zhang Fengfeng, Liu Yongjuan, Chen Xiong, Dong Lanlan, Zhou Bingfei, Cheng Qingqing, Han Song, Liu Zhongchun, Peng Biwen, He Xiaohua, Liu Wanhong
Pathogenic Organism and Infectious Diseases Research Institute, School of Basic Medical Sciences, Wuhan University, Wuhan 430071, China; Hubei Province Key Laboratory of Allergy and Immunology, Wuhan 430071, China.
Pathogenic Organism and Infectious Diseases Research Institute, School of Basic Medical Sciences, Wuhan University, Wuhan 430071, China; College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310014, China.
Biochem Biophys Res Commun. 2015 Mar 20;458(4):810-5. doi: 10.1016/j.bbrc.2015.02.035. Epub 2015 Feb 19.
Enterovirus 71 (EV71) is a neurotropic virus that causes hand, foot and mouth disease (HFMD), occasionally leading to death. As a member of the RAS association domain family (RASSFs), RASSF4 plays important roles in cell death, tumor development and signal transduction. However, little is known about the relationship between RASSF4 and EV71. Our study reveals for the first time that RASSF4 promotes EV71 replication and then accelerates AKT phosphorylation inhibition in EV71-infected 293T cells, suggesting that RASSF4 may be a potential new target for designing therapeutic measures to prevent and control EV71 infection.
肠道病毒71型（EV71）是一种嗜神经病毒，可引起手足口病（HFMD），偶尔会导致死亡。作为RAS关联结构域家族（RASSFs）的成员，RASSF4在细胞死亡、肿瘤发展和信号转导中发挥重要作用。然而，关于RASSF4与EV71之间的关系知之甚少。我们的研究首次揭示，RASSF4促进EV71复制，然后加速EV71感染的293T细胞中AKT磷酸化的抑制，这表明RASSF4可能是设计预防和控制EV71感染治疗措施的潜在新靶点。
