来自植物内生真菌草酸青霉发酵产物的丁内酯衍生物。
Butyrolactones derivatives from the fermentation products of a plant entophytic fungus Penicillium oxalicum.
作者信息
Yuan Lin, Huang Wenzhong, Zhou Kun, Wang Yuede, Dong Wei, Du Gang, Gao Xuemei, Ma Yinhai, Hu Qiufen
机构信息
a Chemical Science and Technology Department, Kunming University , Kunming , 650214 , P.R. China.
出版信息
Nat Prod Res. 2015;29(20):1914-9. doi: 10.1080/14786419.2015.1013473. Epub 2015 Feb 23.
Two new butyrolactone derivatives, terrelactones A and B (1 and 2), together with four known butyrolactone derivatives (3-6), were isolated from the fermentation products of the fungus Penicillium oxalicum 0403. Their structures were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. The anti-tobacco mosaic virus (anti-TMV) activities of 1 and 2 were evaluated. The results showed that compounds 1 and 2 exhibited high anti-TMV activity with inhibition rates of 25.5% and 27.4%, respectively. The inhibition rate is close to that of positive control (28.9%).
从草酸青霉0403的发酵产物中分离出两种新的丁内酯衍生物，terre内酯A和B（1和2），以及四种已知的丁内酯衍生物（3 - 6）。通过光谱方法，包括广泛的一维和二维核磁共振技术对它们的结构进行了阐明。评估了1和2的抗烟草花叶病毒（抗TMV）活性。结果表明，化合物1和2表现出高抗TMV活性，抑制率分别为25.5%和27.4%。抑制率接近阳性对照（28.9%）。
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