头孢菌素H和I，两种源自海洋真菌青霉菌的新型内酯

Cephalosporolides H and I, Two Novel Lactones from a Marine-Derived Fungus, Penicillium sp.

作者信息

Li Xiang, Yao Yanhua, Zheng Yinan, Sattler Isabel, Lin Wenhan

机构信息

Pharmaceutical College of Jilin Agricultural University, Changchun Jilin, 130118, P R. China.

出版信息

Arch Pharm Res. 2007 Jul;30(7):812-5. doi: 10.1007/BF02978829.

DOI:10.1007/BF02978829

PMID:17703730

Abstract

Two novel lactones, Cephalosporolides H (1) and 1 (2), were isolated from the lyophilized culture broth of the marine-derived fungus, Penicillium sp. The structures were elucidated on the basis of extensive 1D- and 2D-NMR, as well as HRESI-MS spectroscopic analyses. The relative stereochemistries of the compounds were assessed by comparison of the NOESY analysis and spectral data with those in the literature.

摘要

从海洋来源的青霉属真菌的冻干培养液中分离出两种新型内酯，头孢菌素内酯H（1）和1（2）。通过广泛的一维和二维核磁共振以及高分辨电喷雾电离质谱光谱分析确定了其结构。通过将NOESY分析和光谱数据与文献中的数据进行比较，评估了化合物的相对立体化学。