Wang Huan, Yang Juan-Xia, Lou Jie, Liu Gui-You, Li Li-Mei, Sun Han-Dong, Xiao Wei-Lie, Hu Qiu-Fen, Gao Xue-Mei
a Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University , Kunming 650031 , China.
J Asian Nat Prod Res. 2015;17(1):27-32. doi: 10.1080/10286020.2014.966697. Epub 2014 Oct 30.
Two new 7,8-secolignans, neglectahenols E and F (1 and 2), together with four known 7,8-secolignans (3-6), were isolated from the fruits of Schisandra neglecta. The structures were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. Compounds 1-6 were tested for their anti-tobacco mosaic virus (anti-TMV) activities at the concentration of 20 μM. Compounds 1 and 6 showed high anti-TMV activities with inhibition rates of 38.2% and 32.7%, respectively. These rates are higher than that of a positive control. Compounds 2-5 also showed modest anti-TMV activities with inhibition rates in the range of 22.8-28.7%. These rates are close to that of a positive control.
从五味子果实中分离得到两个新的7,8-裂环木脂素，即五味子酚E和F（1和2），以及四个已知的7,8-裂环木脂素（3 - 6）。通过光谱方法，包括广泛的一维和二维核磁共振技术对其结构进行了阐明。对化合物1 - 6在20 μM浓度下进行了抗烟草花叶病毒（anti-TMV）活性测试。化合物1和6表现出较高的抗TMV活性，抑制率分别为38.2%和32.7%。这些抑制率高于阳性对照。化合物2 - 5也表现出适度的抗TMV活性，抑制率在22.8 - 28.7%范围内。这些抑制率接近阳性对照。
