CLU基因rs9331888多态性与阿尔茨海默病的遗传关联：一项荟萃分析。
Genetic associations of CLU rs9331888 polymorphism with Alzheimer's disease: A meta-analysis.
作者信息
Shuai Ping, Liu Yuping, Lu Wenxue, Liu Qiaolan, Li Tinxin, Gong Bo
机构信息
Health Management Center, Hospital of University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, Chengdu, Sichuan, China; Sichuan Provincial Key Laboratory for Disease Gene Study, Hospital of University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, Chengdu, Sichuan, China; School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
Health Management Center, Hospital of University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, Chengdu, Sichuan, China; School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
出版信息
Neurosci Lett. 2015 Mar 30;591:160-165. doi: 10.1016/j.neulet.2015.02.040. Epub 2015 Feb 19.
Recent studies showed the Clusterin gene (CLU) is associated with Alzheimer's disease (AD). However, studies investigating the association of CLU single-nucleotide polymorphism (SNP) rs9331888 with AD are controversial. We then performed a meta-analysis to assess the association between CLU SNP rs9331888 and AD. Computerized bibliographic searches of PUBMED and AlzGene database were conducted for the period up to July, 2014. The strength of the association between SNP rs9331888 and AD was estimated by odds ratios (ORs) and OR 95% confidence intervals (CIs). A total of 11 studies composed of 8766 AD cases and 11,366 controls were included in this study. Significant association of SNP rs9331888 with AD was found in Caucasian population among allelic model (C vs. G: OR=1.12, 95%CI=1.06-1.17, P<0.001), additive model (CC vs. GG: OR=1.25, 95%CI=1.12-1.40, P<0.001), recessive model (CC vs. CG+GG: OR=1.20, 95%CI=1.07-1.34, P=0.001), and dominant model (CC+CG vs. GG: OR=1.13, 95%CI=1.06-1.21, P<0.001). No significant association among these models was found in Asian and overall populations. Sensitivity analysis found that one study caused the distinct heterogeneity in Asian subgroup. Our analysis demonstrated that CLU SNP rs9331888 might be associated with an increased AD risk in Caucasian population, but not in Asian population.
近期研究表明，簇集素基因（CLU）与阿尔茨海默病（AD）相关。然而，关于CLU单核苷酸多态性（SNP）rs9331888与AD关联性的研究存在争议。随后我们进行了一项荟萃分析，以评估CLU SNP rs9331888与AD之间的关联性。截至2014年7月，我们利用计算机检索了PUBMED和AlzGene数据库中的文献。通过比值比（OR）和OR 95%置信区间（CI）来估计SNP rs9331888与AD之间关联的强度。本研究共纳入11项研究，包括8766例AD病例和11366例对照。在白种人群中，等位基因模型（C与G：OR = 1.12，95%CI = 1.06 - 1.17，P < 0.001）、加性模型（CC与GG：OR = 1.25，95%CI = 1.12 - 1.40，P < 0.001）、隐性模型（CC与CG + GG：OR = 1.20，95%CI = 1.07 - 1.34，P = 0.001）和显性模型（CC + CG与GG：OR = 1.13，95%CI = 1.06 - 1.21，P < 0.001）中均发现SNP rs9331888与AD存在显著关联。在亚洲人群和总体人群中，这些模型中均未发现显著关联。敏感性分析发现，一项研究导致亚洲亚组存在明显的异质性。我们的分析表明，CLU SNP rs9331888可能与白种人群中AD风险增加相关，但与亚洲人群无关。
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