簇集蛋白变体与中国南方阿尔茨海默病患者无关。
Clusterin variants are not associated with southern Chinese patients with Alzheimer's disease.
作者信息
Lu Shen-Ji, Li Hong-Lei, Sun Yi-Min, Liu Zhi-Jun, Yang Ping, Wu Zhi-Ying
机构信息
Department of Neurology and Institute of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China; Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Shanghai Medical College, Fudan University, Shanghai, China.
Department of Neurology and Institute of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China; Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Shanghai Medical College, Fudan University, Shanghai, China.
出版信息
Neurobiol Aging. 2014 Nov;35(11):2656.e9-2656.e11. doi: 10.1016/j.neurobiolaging.2014.05.015. Epub 2014 May 29.
Recent genome-wide association studies identified clusterin (CLU) to be associated with sporadic Alzheimer's disease. To help clarify the relevance of CLU as genetic determinant of AD, we analyzed its association in southern Chinese Han population. This study comprised 499 sporadic Alzheimer's disease patients and 592 unrelated age- and sex-matched healthy controls. Four single-nucleotide polymorphisms (rs2279590, rs9331888, rs11136000, and rs1532278) within CLU were selected for genotyping. No positive association was found between the CLU variants and AD. Our study suggests that CLU variants may not be an AD susceptibility factor in southern Chinese Han population.
近期全基因组关联研究确定簇集蛋白（CLU）与散发性阿尔茨海默病相关。为了阐明CLU作为阿尔茨海默病遗传决定因素的相关性，我们分析了其在中国南方汉族人群中的关联性。本研究纳入了499例散发性阿尔茨海默病患者和592例年龄及性别匹配的无亲缘关系健康对照。选择CLU基因内的4个单核苷酸多态性（rs2279590、rs9331888、rs11136000和rs1532278）进行基因分型。未发现CLU变异与阿尔茨海默病之间存在正相关。我们的研究表明，在中国南方汉族人群中，CLU变异可能不是阿尔茨海默病的易感性因素。
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