Zhang Shuyan, Zhang Donghui, Jiang Yongshuai, Wu Lina, Shang Hong, Liu Jiafeng, Feng Rennan, Liao Mingzhi, Zhang Liangcai, Liu Yong, Liu Guiyou, Li Keshen
Department of Neurology, The Forth Affiliated Hospital of Harbin Medical University, Harbin, China.
J Neural Transm (Vienna). 2015 Mar;122(3):433-9. doi: 10.1007/s00702-014-1260-9. Epub 2014 Jun 20.
It is reported that CLU rs2279590 polymorphism is significantly associated with Alzheimer's disease (AD) in European ancestry. Recent studies investigated rs2279590 polymorphism in Asian population (Chinese, Japanese and Korean). Four studies showed negative association and two studies showed weak association between rs2279590 and AD. We believe that the weak association or no association may be caused by the relatively small sample size in Asian population. Here, we reinvestigated the association in Asian population. Meanwhile, to investigate the genetic heterogeneity of the rs2279590 polymorphism in Asian and Caucasian populations, we searched the PubMed and AlzGene databases and selected 11 independent studies (6 studies in Asian population and 5 studies in Caucasian population) including 20,655 individuals (8,605 cases and 12,050 controls) for meta-analysis. Our results showed significant association between rs2279590 polymorphism and AD in Asian population with P = 2.00E-04 and P = 2.00E-04 using additive and recessive models, respectively. We observed no significant heterogeneity between Asian and Caucasian populations. We believe that our results may be helpful to understand the mechanisms of CLU in AD pathogenesis and will be useful for future genetic studies in AD.
据报道，CLU基因rs2279590多态性在欧洲血统人群中与阿尔茨海默病（AD）显著相关。近期研究调查了亚洲人群（中国人、日本人及韩国人）中的rs2279590多态性。四项研究显示rs2279590与AD之间呈负相关，两项研究显示呈弱相关。我们认为这种弱相关或无关联可能是由于亚洲人群样本量相对较小所致。在此，我们重新调查了亚洲人群中的这种关联。同时，为研究亚洲和白种人群中rs2279590多态性的遗传异质性，我们检索了PubMed和AlzGene数据库，并选择了11项独立研究（6项亚洲人群研究和5项白种人群研究），共20655例个体（8605例病例和12050例对照）进行荟萃分析。我们的结果显示，在亚洲人群中，rs2279590多态性与AD显著相关，采用加性模型和隐性模型时P值分别为2.00E - 04和2.00E - 04。我们观察到亚洲和白种人群之间无显著异质性。我们相信我们的结果可能有助于理解CLU在AD发病机制中的作用，并将对未来AD的遗传学研究有用。
