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Effect of ATP and amiloride on ANF binding and stimulation of cyclic GMP accumulation in rat glomerular membranes.

作者信息

Cole F E, Rondon I, Iwata T, Hardee E, Frohlich E D

机构信息

Alton Ochsner Medical Foundation, New Orleans, Louisiana 70121.

出版信息

Life Sci. 1989;45(6):477-84. doi: 10.1016/0024-3205(89)90097-0.

DOI:10.1016/0024-3205(89)90097-0
PMID:2570337
Abstract

We investigated ANF binding and stimulation of cGMP accumulation in isolated rat glomerular membranes in the presence and absence of amiloride and ATP. Amiloride enhanced high affinity binding of ANF without affecting its stimulation of cGMP. In contrast ATP decreased binding and decreased basal cGMP accumulation without affecting the ability of ANF to stimulate cGMP. These data indicate that ANF binding and stimulation of cGMP accumulation can be regulated independently supporting further the concept of receptor heterogeneity in renal glomerular membranes.

摘要

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引用本文的文献

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Atrial natriuretic factor receptor guanylate cyclase, ANF-RGC, transduces two independent signals, ANF and Ca(2+).心房利钠因子受体鸟苷酸环化酶（ANF-RGC）可转导两种独立信号，即心房利钠因子（ANF）和钙离子（Ca²⁺）。
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ATP signaling site in the ARM domain of atrial natriuretic factor receptor guanylate cyclase.
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