Effect of voluntary physical activity initiated at age 7 months on skeletal hindlimb and cardiac muscle function in mdx mice of both genders.
作者信息
Ferry Arnaud, Benchaouir Rachid, Joanne Pierre, Peat Rachel A, Mougenot Nathalie, Agbulut Onnik, Butler-Browne Gillian
机构信息
Université Pierre et Marie Curie-Paris 6, Sorbonne Universités, UMR S794, INSERM, U974, CNRS UMR 7215, Institut de Myologie, Paris, France.
Université Paris Descartes, Sorbonne Paris Cité, Paris, France.
出版信息
Muscle Nerve. 2015 Nov;52(5):788-94. doi: 10.1002/mus.24604. Epub 2015 Sep 3.
INTRODUCTION
The effects of voluntary activity initiated in adult mdx (C57BL/10ScSc-DMD(mdx) /J) mice on skeletal and cardiac muscle function have not been studied extensively.
METHODS
We studied the effects of 3 months of voluntary wheel running initiated at age 7 months on hindlimb muscle weakness, increased susceptibility to muscle contraction-induced injury, and left ventricular function in mdx mice.
RESULTS
We found that voluntary wheel running did not worsen the deficit in force-generating capacity and the force drop after lengthening contractions in either mdx mouse gender. It increased the absolute maximal force of skeletal muscle in female mdx mice. Moreover, it did not affect left ventricular function, structural heart dimensions, cardiac gene expression of inflammation, fibrosis, or remodeling markers.
CONCLUSION
These results indicate that voluntary activity initiated at age 7 months had no detrimental effects on skeletal or cardiac muscles in either mdx mouse gender.
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