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用于质子放射治疗的液体闪烁体的闪烁体与水阻止本领比的计算与测量。

Calculations and measurements of the scintillator-to-water stopping power ratio of liquid scintillators for use in proton radiotherapy.

作者信息

Ingram W Scott, Robertson Daniel, Beddar Sam

机构信息

Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA ; The University of Texas Graduate School of Biomedical Sciences at Houston, Houston, TX 77030, USA.

Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

出版信息

Nucl Instrum Methods Phys Res A. 2015 Mar 11;776:15-20. doi: 10.1016/j.nima.2014.12.004.

Abstract

Liquid scintillators are a promising detector for high-resolution three-dimensional proton therapy dosimetry. Because the scintillator comprises both the active volume of the detector and the phantom material, an ideal scintillator will exhibit water equivalence in its radiological properties. One of the most fundamental of these is the scintillator's stopping power. The objective of this study was to compare calculations and measurements of scintillator-to-water stopping power ratios to evaluate the suitability of the liquid scintillators BC-531 and OptiPhase HiSafe 3 for proton dosimetry. We also measured the relative scintillation output of the two scintillators. Both calculations and measurements show that the linear stopping power of OptiPhase is significantly closer to water than that of BC-531. BC-531 has a somewhat higher scintillation output. OptiPhase can be mixed with water at high concentrations, which further improves its scintillator-to-water stopping power ratio. However, this causes the solution to become cloudy, which has a negative impact on the scintillation output and spatial resolution of the detector. OptiPhase is preferred over BC-531 for proton dosimetry because its density and scintillator-to-water stopping power ratio are more water equivalent.

摘要

液体闪烁体是用于高分辨率三维质子治疗剂量测定的一种很有前景的探测器。由于闪烁体既构成探测器的有效体积又构成模体材料,理想的闪烁体在其放射学特性上应表现出与水等效。其中最基本的特性之一就是闪烁体的阻止本领。本研究的目的是比较闪烁体与水的阻止本领比的计算值和测量值,以评估液体闪烁体BC - 531和OptiPhase HiSafe 3用于质子剂量测定的适用性。我们还测量了这两种闪烁体的相对闪烁输出。计算和测量结果均表明,OptiPhase的线性阻止本领比BC - 531更接近水的阻止本领。BC - 531的闪烁输出略高。OptiPhase可以与高浓度的水混合,这进一步提高了其闪烁体与水的阻止本领比。然而,这会使溶液变浑浊,对探测器的闪烁输出和空间分辨率产生负面影响。在质子剂量测定中,OptiPhase比BC - 531更受青睐,因为其密度和闪烁体与水的阻止本领比更接近水等效。

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