• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

在计算机模拟中鉴定分泌型卷曲相关蛋白1（SFRP1）为结直肠癌中的高甲基化基因。

In silico Identification of SFRP1 as a Hypermethylated Gene in Colorectal Cancers.

作者信息

Kim Jongbum, Kim Sangsoo

机构信息

Department of Bioinformatics and Life Science, Soongsil University, Seoul 156-743, Korea.

出版信息

Genomics Inform. 2014 Dec;12(4):171-80. doi: 10.5808/GI.2014.12.4.171. Epub 2014 Dec 31.

DOI:10.5808/GI.2014.12.4.171
PMID:25705155
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4330251/
Abstract

Aberrant DNA methylation, as an epigenetic marker of cancer, influences tumor development and progression. We downloaded publicly available DNA methylation and gene expression datasets of matched cancer and normal pairs from the Cancer Genome Atlas Data Portal and performed a systematic computational analysis. This study has three aims to screen genes that show hypermethylation and downregulated patterns in colorectal cancers, to identify differentially methylated regions in one of these genes, SFRP1, and to test whether the SFRP genes affect survival or not. Our results show that 31 hypermethylated genes had a negative correlation with gene expression. Among them, SFRP1 had a differentially methylated pattern at each methylation site. We also show that SFRP1 may be a potential biomarker for colorectal cancer survival.

摘要

异常DNA甲基化作为癌症的一种表观遗传标志物，影响肿瘤的发生和进展。我们从癌症基因组图谱数据门户下载了公开可用的匹配癌症与正常样本对的DNA甲基化和基因表达数据集，并进行了系统的计算分析。本研究有三个目标：筛选在结直肠癌中呈现高甲基化和下调模式的基因；鉴定其中一个基因SFRP1的差异甲基化区域；测试SFRP基因是否影响生存率。我们的结果表明，31个高甲基化基因与基因表达呈负相关。其中，SFRP1在每个甲基化位点都有差异甲基化模式。我们还表明，SFRP1可能是结直肠癌生存的一个潜在生物标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a82/4330251/0e27994dedd9/gni-12-171-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a82/4330251/a86bd751d20b/gni-12-171-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a82/4330251/28005f5d8747/gni-12-171-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a82/4330251/de8d275f98e4/gni-12-171-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a82/4330251/6ae5d1698309/gni-12-171-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a82/4330251/76e25853d790/gni-12-171-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a82/4330251/f6e0ab2066b7/gni-12-171-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a82/4330251/ab186f01eb8f/gni-12-171-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a82/4330251/9e246eed5fa4/gni-12-171-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a82/4330251/e170b4e6dafc/gni-12-171-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a82/4330251/46d7db86c920/gni-12-171-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a82/4330251/79fc6c8d4aa4/gni-12-171-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a82/4330251/0e27994dedd9/gni-12-171-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a82/4330251/a86bd751d20b/gni-12-171-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a82/4330251/28005f5d8747/gni-12-171-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a82/4330251/de8d275f98e4/gni-12-171-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a82/4330251/6ae5d1698309/gni-12-171-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a82/4330251/76e25853d790/gni-12-171-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a82/4330251/f6e0ab2066b7/gni-12-171-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a82/4330251/ab186f01eb8f/gni-12-171-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a82/4330251/9e246eed5fa4/gni-12-171-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a82/4330251/e170b4e6dafc/gni-12-171-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a82/4330251/46d7db86c920/gni-12-171-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a82/4330251/79fc6c8d4aa4/gni-12-171-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3a82/4330251/0e27994dedd9/gni-12-171-g012.jpg

相似文献

1
In silico Identification of SFRP1 as a Hypermethylated Gene in Colorectal Cancers.在计算机模拟中鉴定分泌型卷曲相关蛋白1（SFRP1）为结直肠癌中的高甲基化基因。
Genomics Inform. 2014 Dec;12(4):171-80. doi: 10.5808/GI.2014.12.4.171. Epub 2014 Dec 31.
2
Aging related methylation influences the gene expression of key control genes in colorectal cancer and adenoma.衰老相关的甲基化影响结直肠癌和腺瘤中关键调控基因的基因表达。
World J Gastroenterol. 2016 Dec 21;22(47):10325-10340. doi: 10.3748/wjg.v22.i47.10325.
3
Hypermethylation and expression regulation of secreted frizzled-related protein genes in colorectal tumor.结直肠癌中分泌型卷曲相关蛋白基因的高甲基化与表达调控
World J Gastroenterol. 2006 Nov 28;12(44):7113-7. doi: 10.3748/wjg.v12.i44.7113.
4
[Hypermethylation and regulation of expression of secreted frizzled-related protein genes in colorectal tumor].[结直肠癌中分泌型卷曲相关蛋白基因的高甲基化及其表达调控]
Zhonghua Zhong Liu Za Zhi. 2007 Nov;29(11):842-5.
5
Aberrant methylation of secreted frizzled-related protein genes in esophageal adenocarcinoma and Barrett's esophagus.食管腺癌和巴雷特食管中分泌型卷曲相关蛋白基因的异常甲基化。
Int J Cancer. 2005 Sep 10;116(4):584-91. doi: 10.1002/ijc.21045.
6
Aberrant DNA methylation of WNT pathway genes in the development and progression of CIMP-negative colorectal cancer.WNT信号通路基因的异常DNA甲基化在CIMP阴性结直肠癌的发生发展过程中的作用
Epigenetics. 2016 Aug 2;11(8):588-602. doi: 10.1080/15592294.2016.1190894. Epub 2016 May 31.
7
Genome-wide methylation profiling identified novel differentially hypermethylated biomarker MPPED2 in colorectal cancer.全基因组甲基化分析鉴定出结直肠癌中新的差异超甲基化生物标志物 MPPED2。
Clin Epigenetics. 2019 Mar 7;11(1):41. doi: 10.1186/s13148-019-0628-y.
8
DNA hypermethylation and decreased mRNA expression of MAL, PRIMA1, PTGDR and SFRP1 in colorectal adenoma and cancer.结直肠腺瘤和癌中 MAL、PRIMA1、PTGDR 和 SFRP1 的 DNA 高甲基化及 mRNA 表达降低
BMC Cancer. 2015 Oct 19;15:736. doi: 10.1186/s12885-015-1687-x.
9
Prognostic Relevance of SFRP1 Gene Promoter Methylation in Colorectal Carcinoma.SFRP1基因启动子甲基化在结直肠癌中的预后相关性
Asian Pac J Cancer Prev. 2019 May 25;20(5):1571-1577. doi: 10.31557/APJCP.2019.20.5.1571.
10
Hypermethylated Promoters of Secreted Frizzled-Related Protein Genes are Associated with Colorectal Cancer.分泌型卷曲相关蛋白基因的高甲基化启动子与结直肠癌相关。
Pathol Oncol Res. 2019 Apr;25(2):567-575. doi: 10.1007/s12253-018-0505-6. Epub 2018 Oct 27.

引用本文的文献

1
MicroRNA-27a targets Sfrp1 to induce renal fibrosis in diabetic nephropathy by activating Wnt/β-Catenin signalling.微小 RNA-27a 通过激活 Wnt/β-连环蛋白信号通路靶向 Sfrp1 诱导糖尿病肾病肾纤维化。
Biosci Rep. 2020 Jun 26;40(6). doi: 10.1042/BSR20192794.
2
Epigenetics of : The Dual Roles in Human Cancers.表观遗传学：在人类癌症中的双重作用。 （注：原文标题表述不太完整规范，推测完整标题可能类似这样，根据实际情况可能需要调整）
Cancers (Basel). 2020 Feb 14;12(2):445. doi: 10.3390/cancers12020445.
3
Methylation of secreted frizzled-related protein 1 (SFRP1) promoter downregulates Wnt/β-catenin activity in keloids.

本文引用的文献

1
DNA methylation as clinically useful biomarkers-light at the end of the tunnel.DNA 甲基化作为具有临床应用价值的生物标志物——隧道尽头的光。
Pharmaceuticals (Basel). 2012 Jan 18;5(1):94-113. doi: 10.3390/ph5010094.
2
Decreased expression and aberrant hypermethylation of the SFRP genes in human gastric cancer.人胃癌中SFRP基因表达降低及异常高甲基化
Hepatogastroenterology. 2011 May-Jun;58(107-108):1051-6.
3
Comparison of Beta-value and M-value methods for quantifying methylation levels by microarray analysis.比较微阵列分析中用于定量甲基化水平的 Beta 值法和 M 值法。
分泌卷曲相关蛋白 1（SFRP1）启动子甲基化下调瘢痕疙瘩中的 Wnt/β-连环蛋白活性。
J Mol Histol. 2018 Apr;49(2):185-193. doi: 10.1007/s10735-018-9758-3. Epub 2018 Feb 17.
4
Hilbert-Schmidt and Sobol sensitivity indices for static and time series Wnt signaling measurements in colorectal cancer - part A.用于结直肠癌中静态和时间序列Wnt信号测量的希尔伯特-施密特和索博尔灵敏度指数 - A部分。
BMC Syst Biol. 2017 Dec 4;11(1):120. doi: 10.1186/s12918-017-0488-z.
5
Colorectal adenoma and cancer detection based on altered methylation pattern of SFRP1, SFRP2, SDC2, and PRIMA1 in plasma samples.基于 SFRP1、SFRP2、SDC2 和 PRIMA1 血浆样本中甲基化模式改变对结直肠腺瘤和癌症的检测。
Epigenetics. 2017 Sep;12(9):751-763. doi: 10.1080/15592294.2017.1356957. Epub 2017 Sep 26.
6
Aging related methylation influences the gene expression of key control genes in colorectal cancer and adenoma.衰老相关的甲基化影响结直肠癌和腺瘤中关键调控基因的基因表达。
World J Gastroenterol. 2016 Dec 21;22(47):10325-10340. doi: 10.3748/wjg.v22.i47.10325.
BMC Bioinformatics. 2010 Nov 30;11:587. doi: 10.1186/1471-2105-11-587.
4
Aberrant epigenetic landscape in cancer: how cellular identity goes awry.癌症中异常的表观遗传景观：细胞身份如何出错。
Dev Cell. 2010 Nov 16;19(5):698-711. doi: 10.1016/j.devcel.2010.10.005.
5
Hypermethylation and aberrant expression of secreted frizzled-related protein genes in pancreatic cancer.胰腺癌中分泌型卷曲相关蛋白基因的高甲基化与异常表达
World J Gastroenterol. 2008 Jun 7;14(21):3421-4. doi: 10.3748/wjg.14.3421.
6
Epigenetics in cancer.癌症中的表观遗传学
N Engl J Med. 2008 Mar 13;358(11):1148-59. doi: 10.1056/NEJMra072067.
7
Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project.ENCODE试点项目对人类基因组1%的功能元件进行鉴定与分析。
Nature. 2007 Jun 14;447(7146):799-816. doi: 10.1038/nature05874.
8
DNA methylation as a therapeutic target in cancer.DNA甲基化作为癌症的治疗靶点。
Clin Cancer Res. 2007 Mar 15;13(6):1634-7. doi: 10.1158/1078-0432.CCR-06-2076.
9
Hypermethylation and expression regulation of secreted frizzled-related protein genes in colorectal tumor.结直肠癌中分泌型卷曲相关蛋白基因的高甲基化与表达调控
World J Gastroenterol. 2006 Nov 28;12(44):7113-7. doi: 10.3748/wjg.v12.i44.7113.
10
Aberrant methylation of the Wnt antagonist SFRP1 in breast cancer is associated with unfavourable prognosis.乳腺癌中Wnt拮抗剂SFRP1的异常甲基化与不良预后相关。
Oncogene. 2006 Jun 8;25(24):3479-88. doi: 10.1038/sj.onc.1209386. Epub 2006 Jan 30.