Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet de Llobregat, 08907 Barcelona, Catalonia, Spain.
Dev Cell. 2010 Nov 16;19(5):698-711. doi: 10.1016/j.devcel.2010.10.005.
Appropriate patterns of DNA methylation and histone modifications are required to assure cell identity, and their deregulation can contribute to human diseases, such as cancer. Our aim here is to provide an overview of how epigenetic factors, including genomic DNA methylation, histone modifications, and microRNA regulation, contribute to normal development, paying special attention to their role in regulating tissue-specific genes. In addition, we summarize how these epigenetic patterns go awry during human cancer development. The possibility of "resetting" the abnormal cancer epigenome by applying pharmacological or genetic strategies is also discussed.
适当的 DNA 甲基化和组蛋白修饰模式是保证细胞身份的必要条件，其失调可能导致人类疾病，如癌症。我们的目的是提供一个概述，说明包括基因组 DNA 甲基化、组蛋白修饰和 microRNA 调节在内的表观遗传因素如何促进正常发育，并特别关注它们在调节组织特异性基因中的作用。此外，我们总结了这些表观遗传模式在人类癌症发展过程中是如何出错的。通过应用药理学或遗传学策略“重置”异常的癌症表观基因组的可能性也将进行讨论。
