Bester-Meredith Janet K, Fancher Alexandria P, Mammarella Grace E
Department of Biology, Seattle Pacific University , Seattle, WA , USA.
Front Endocrinol (Lausanne). 2015 Feb 5;6:5. doi: 10.3389/fendo.2015.00005. eCollection 2015.
As mammals develop, they encounter increasing social complexity in the surrounding world. In order to survive, mammals must show appropriate behaviors toward their mates, offspring, and same-sex conspecifics. Although the behavioral effects of the neuropeptide arginine vasopressin (AVP) have been studied in a variety of social contexts, the effects of this neuropeptide on multimodal sensory processing have received less attention. AVP is widely distributed through sensory regions of the brain and has been demonstrated to modulate olfactory, auditory, gustatory, and visual processing. Here, we review the evidence linking AVP to the processing of social stimuli in sensory regions of the brain and explore how sensory processing can shape behavioral responses to these stimuli. In addition, we address the interplay between hormonal and neural AVP in regulating sensory processing of social cues. Because AVP pathways show plasticity during development, early life experiences may shape life-long processing of sensory information. Furthermore, disorders of social behavior such as autism and schizophrenia that have been linked with AVP also have been linked with dysfunctions in sensory processing. Together, these studies suggest that AVP's diversity of effects on social behavior across a variety of mammalian species may result from the effects of this neuropeptide on sensory processing.
随着哺乳动物的发育，它们在周围世界中会遇到日益复杂的社会环境。为了生存，哺乳动物必须对其配偶、后代和同性同类表现出适当的行为。尽管神经肽精氨酸加压素（AVP）的行为效应已在各种社会背景下进行了研究，但这种神经肽对多模态感觉加工的影响却较少受到关注。AVP广泛分布于大脑的感觉区域，并已被证明可调节嗅觉、听觉、味觉和视觉加工。在此，我们回顾将AVP与大脑感觉区域中社会刺激加工联系起来的证据，并探讨感觉加工如何塑造对这些刺激的行为反应。此外，我们还讨论了激素和神经AVP在调节社会线索感觉加工中的相互作用。由于AVP通路在发育过程中具有可塑性，早期生活经历可能会塑造终身的感觉信息加工。此外，与AVP相关的社会行为障碍，如自闭症和精神分裂症，也与感觉加工功能障碍有关。总之，这些研究表明，AVP对多种哺乳动物物种社会行为的多样影响可能源于这种神经肽对感觉加工的影响。
