偏头痛中是否存在神经血管耦合的持续性功能障碍？
Is there a persistent dysfunction of neurovascular coupling in migraine?
作者信息
Fabjan Andrej, Zaletel Marjan, Žvan Bojana
机构信息
Institute of Physiology, Medical Faculty, University of Ljubljana, Zaloška Cesta 4, 1000 Ljubljana, Slovenia.
Department of Vascular Neurology, University Clinical Centre, Zaloška Cesta 2, 1000 Ljubljana, Slovenia.
出版信息
Biomed Res Int. 2015;2015:574186. doi: 10.1155/2015/574186. Epub 2015 Feb 1.
Abstract
Changes in cerebral blood flow are one of the main features of migraine attack and have inspired the vascular theory of migraine. This traditional view has been reshaped with recent experimental data, which gave rise to the neural theory of migraine. In this review, we speculate that there might be an important link between the two theories, that is, the dysfunction of neurovascular coupling.
摘要
脑血流量的变化是偏头痛发作的主要特征之一，激发了偏头痛的血管学说。这一传统观点已随着近期的实验数据而重塑，进而产生了偏头痛的神经学说。在本综述中，我们推测这两种学说之间可能存在重要联系，即神经血管耦合功能障碍。
相似文献
1
Is there a persistent dysfunction of neurovascular coupling in migraine?偏头痛中是否存在神经血管耦合的持续性功能障碍？
Biomed Res Int. 2015;2015:574186. doi: 10.1155/2015/574186. Epub 2015 Feb 1.
2
Study of neurovascular coupling during cold pressor test in patients with migraine.偏头痛患者冷加压试验期间神经血管耦合的研究。
Cephalalgia. 2015 Jul;35(8):692-701. doi: 10.1177/0333102414554661. Epub 2014 Oct 20.
3
Profiling cerebrovascular function in migraine: A systematic review and meta-analysis.偏头痛患者脑血管功能剖析：一项系统评价与荟萃分析。
J Cereb Blood Flow Metab. 2021 May;41(5):919-944. doi: 10.1177/0271678X20964344. Epub 2020 Oct 22.
4
Posterior hypoperfusion in migraine without aura?无先兆偏头痛中的后循环灌注不足？
Cephalalgia. 2010 Aug;30(8):1018; author reply 1018-20. doi: 10.1111/j.1468-2982.2009.01949.x.
5
An update on the blood vessel in migraine.偏头痛血管研究进展。
Curr Opin Neurol. 2010 Jun;23(3):266-74. doi: 10.1097/WCO.0b013e32833821c1.
6
[Monitoring cerebral blood volume changes during migraine attack by using near-infrared spectroscopy].[利用近红外光谱技术监测偏头痛发作期间脑血容量变化]
Rinsho Shinkeigaku. 2012;52(11):1009-11. doi: 10.5692/clinicalneurol.52.1009.
7
[Cerebral blood flow in migraine without aura].[无先兆偏头痛的脑血流量]
Pathol Biol (Paris). 1992 Apr;40(4):325-31.
8
A critical view on the role of migraine triggers in the genesis of migraine pain.对偏头痛触发因素在偏头痛疼痛发生中作用的批判性观点。
Headache. 2009 Jun;49(6):953-7. doi: 10.1111/j.1526-4610.2009.01444.x.
9
Migraine and cerebral blood flow in the general population.普通人群中的偏头痛与脑血流量
Cephalalgia. 2015 Feb;35(2):190-8. doi: 10.1177/0333102414552531. Epub 2014 Oct 3.
10
Reduced breath holding index in patients with chronic migraine.慢性偏头痛患者的屏气指数降低。
Acta Neurol Belg. 2015 Sep;115(3):323-7. doi: 10.1007/s13760-014-0375-y. Epub 2014 Oct 12.
引用本文的文献
1
Targeting Na,K-ATPase-Src signaling to normalize cerebral blood flow in a murine model of familial hemiplegic migraine.在家族性偏瘫性偏头痛小鼠模型中，靶向钠钾ATP酶-Src信号通路以恢复脑血流正常化
J Cereb Blood Flow Metab. 2025 May;45(5):842-854. doi: 10.1177/0271678X241305562. Epub 2024 Dec 4.
2
Harnessing Miniscope Imaging in Freely Moving Animals to Unveil Migraine Pathophysiology and Validate Novel Therapeutic Strategies.利用微型显微镜成像在自由活动的动物中揭示偏头痛发病机制并验证新的治疗策略。
Synapse. 2024 Nov;78(6):e70001. doi: 10.1002/syn.70001.
3
Reduced neurovascular coupling of the visual network in migraine patients with aura as revealed with arterial spin labeling MRI: is there a demand-supply mismatch behind the scenes?偏头痛先兆患者的视觉网络神经血管耦合减少：幕后是否存在供需不匹配？
J Headache Pain. 2024 Oct 15;25(1):180. doi: 10.1186/s10194-024-01885-1.
4
Hypoperfusion of periaqueductal gray as an imaging biomarker in chronic migraine beyond diagnosis: A 3D pseudocontinuous arterial spin labeling MR imaging.脑桥水管周围灰质低灌注作为慢性偏头痛的影像学生物标志物：3D 伪连续动脉自旋标记磁共振成像。
Brain Behav. 2024 Sep;14(9):e70008. doi: 10.1002/brb3.70008.
5
Altered cerebral neurovascular coupling in medication-overuse headache: A study combining multi-modal resting-state fMRI with 3D PCASL.药物过量使用性头痛中脑血流神经血管耦合的改变：一项将多模态静息态功能磁共振成像与三维相位对比动脉自旋标记相结合的研究
Front Neurosci. 2023 Mar 15;17:1139086. doi: 10.3389/fnins.2023.1139086. eCollection 2023.
6
Studies on the Mechanism of Glutamate Metabolism in NTG-Induced Migraine Rats Treated with DCXF.二陈芎香方治疗硝酸甘油诱导偏头痛大鼠的谷氨酸代谢机制研究
Evid Based Complement Alternat Med. 2019 Dec 31;2019:1324797. doi: 10.1155/2019/1324797. eCollection 2019.
本文引用的文献
1
Study of neurovascular coupling during cold pressor test in patients with migraine.偏头痛患者冷加压试验期间神经血管耦合的研究。
Cephalalgia. 2015 Jul;35(8):692-701. doi: 10.1177/0333102414554661. Epub 2014 Oct 20.
2
A critical role for the vascular endothelium in functional neurovascular coupling in the brain.血管内皮在大脑功能性神经血管耦合中起关键作用。
J Am Heart Assoc. 2014 Jun 12;3(3):e000787. doi: 10.1161/JAHA.114.000787.
3
From different neurophysiological methods to conflicting pathophysiological views in migraine: a critical review of literature.从不同的神经生理学方法到偏头痛中相互矛盾的病理生理学观点：文献综述。
Clin Neurophysiol. 2014 Sep;125(9):1721-30. doi: 10.1016/j.clinph.2014.05.005. Epub 2014 May 19.
4
Serotonin depletion can enhance the cerebrovascular responses induced by cortical spreading depression via the nitric oxide pathway.血清素耗竭可通过一氧化氮途径增强皮层扩散性抑制诱导的脑血管反应。
Int J Neurosci. 2015 Feb;125(2):130-9. doi: 10.3109/00207454.2014.908876. Epub 2014 May 19.
5
Interictal "patchy" regional cerebral blood flow patterns in migraine patients. A single photon emission computerized tomographic study.偏头痛患者发作间期“斑片状”区域性脑血流模式。单光子发射计算机断层扫描研究。
Eur J Neurol. 1994 Sep;1(1):35-43. doi: 10.1111/j.1468-1331.1994.tb00048.x.
6
Brain activations in the premonitory phase of nitroglycerin-triggered migraine attacks.硝酸甘油诱发偏头痛发作前导期的大脑激活。
Brain. 2014 Jan;137(Pt 1):232-41. doi: 10.1093/brain/awt320. Epub 2013 Nov 25.
7
Multimodal assessment of optokinetic visual stimulation response in migraine with aura.偏头痛伴先兆的视动刺激反应的多模态评估。
Headache. 2014 Jan;54(1):131-41. doi: 10.1111/head.12194. Epub 2013 Aug 23.
8
Habituation and sensitization in primary headaches.原发性头痛的习惯化和敏化。
J Headache Pain. 2013 Jul 30;14(1):65. doi: 10.1186/1129-2377-14-65.
9
Migraine pathophysiology: anatomy of the trigeminovascular pathway and associated neurological symptoms, cortical spreading depression, sensitization, and modulation of pain.偏头痛发病机制：三叉血管通路解剖及相关神经症状、皮质扩散性抑制、敏化和疼痛调制。
Pain. 2013 Dec;154 Suppl 1:S44-53. doi: 10.1016/j.pain.2013.07.021. Epub 2013 Jul 25.
10
Cortical spreading depression as a target for anti-migraine agents.皮质扩散性抑制作为抗偏头痛药物的作用靶点。
J Headache Pain. 2013 Jul 23;14(1):62. doi: 10.1186/1129-2377-14-62.
Zotero 插件