维库溴铵用于烧伤患儿的神经肌肉阻滞作用
Neuromuscular blockade with vecuronium in paediatric patients with burn injury.
作者信息
Mills A K, Martyn J A
机构信息
Department of Anaesthesiology, Harvard Medical School, Boston, MA.
出版信息
Br J Clin Pharmacol. 1989 Aug;28(2):155-9. doi: 10.1111/j.1365-2125.1989.tb05408.x.
Abstract
- The effect of body surface area (BSA) burn injury on neuromuscular pharmacodynamics of vecuronium was evaluated. 2. The neuromuscular responses of 15 burned children were compared with those in five controls. 3. The effective dose for 50% suppression of twitch tension (ED50) was 34 micrograms kg-1 for patients with less than 40% BSA burn, 55 micrograms kg-1 for 40-60% BSA burn, and 65 micrograms kg-1 for patients with greater than 60% BSA burn. These values were significantly higher than the value for control patients, which was 18 micrograms kg-1. 4. Burn injury induces a resistance to the neuromuscular effects of vecuronium, the magnitude of which is related to burn size.
摘要
- 评估了体表面积（BSA）烧伤对维库溴铵神经肌肉药效学的影响。2. 将15名烧伤儿童的神经肌肉反应与5名对照者的反应进行了比较。3. 对于BSA烧伤小于40%的患者，抑制抽搐张力50%的有效剂量（ED50）为34微克/千克；对于40%-60% BSA烧伤的患者，为55微克/千克；对于BSA烧伤大于60%的患者，为65微克/千克。这些值显著高于对照患者的18微克/千克。4. 烧伤会导致对维库溴铵神经肌肉作用产生抵抗，其程度与烧伤面积有关。
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本文引用的文献
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