[低浓度奎宁的水溶液和盐溶液：自组织、物理化学性质及其对神经元电特性的作用]
[Aqueous and salt solutions of quinine of low concentrations: self-organization, physicochemical properties and actions on the electrical characteristics of neurons].
作者信息
Murtazina L I, Ryzhkina I S, Mishina O A, Andrianov V V, Bogodvid T Kh, Gaĭnutdinov Kh L, Muranova L N, Konovalov A I
出版信息
Biofizika. 2014 Jul-Aug;59(4):717-22.
Self-organization, the physicochemical properties of aqueous and salt solutions of quinine and the effects of salt quinine solutions in a wide range of concentrations (1 x 10(-22) - 1 x 10(-3) M) on the electrical characteristics of the edible snail's identified neurons were studied. Similar non-monotonic concentration dependencies of physicochemical properties of aqueous and salt quinine solutions at low concentrations are obtained. This allows of predicting the occurrence of biological effects at low concentrations of quinine solutions. Intrinsic (within 5% of the interval) changes in membrane potential, the amplitude and duration of the neuron action potential under the influence of quinine salt solutions at concentrations of quinine of 1 x 10(-20), 1 x 10(-18), 1 x 10(-10) M are found. For these concentrations the extreme values of specific conductivity and pH are shown.
研究了自组织、奎宁水溶液和盐溶液的物理化学性质，以及不同浓度范围（1×10⁻²² - 1×10⁻³ M）的奎宁盐溶液对可食用蜗牛特定神经元电特性的影响。在低浓度下，获得了类似的奎宁水溶液和盐溶液物理化学性质的非单调浓度依赖性。这使得能够预测低浓度奎宁溶液时生物效应的发生。发现在奎宁浓度为1×10⁻²⁰、1×10⁻¹⁸、1×10⁻¹⁰ M的奎宁盐溶液影响下，膜电位、神经元动作电位的幅度和持续时间存在内在（在区间的5%以内）变化。对于这些浓度，给出了电导率和pH的极值。
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