DeMars L R, Van Le L, Huang I, Fowler W C
Department of Obstetrics and Gynecology, University of North Carolina, Chapel Hill 27599-7570, USA.
Gynecol Oncol. 1995 Sep;58(3):389-92. doi: 10.1006/gyno.1995.1249.
The association between in utero diethylstilbestrol (DES) exposure and the development of clear-cell adenocarcinoma of the vagina and cervix has been well described. However, non-clear-cell mucin-secreting adenocarcinoma in women with DES exposure has not been previously reported. We present two cases of non-clear-cell mucinous adenocarcinoma in women having a history of in utero DES exposure. These cancers were found in older women and were more advanced than the clear-cell adenocarcinoma associated with DES. Histologic features of these tumors were notable for atypical, irregular glands lined by endocervical, intestinal, and endometrioid epithelium. The development of non-clear-cell adenocarcinoma of the vagina in these patients may be associated with DES exposure in utero. Long-term surveillance of DES-exposed women may be warranted.
子宫内己烯雌酚（DES）暴露与阴道和宫颈透明细胞腺癌的发生之间的关联已得到充分描述。然而，先前尚未报道过DES暴露女性发生非透明细胞黏液分泌腺癌的情况。我们报告了两例有子宫内DES暴露史的女性发生非透明细胞黏液腺癌的病例。这些癌症发生在老年女性中，且比与DES相关的透明细胞腺癌更晚期。这些肿瘤的组织学特征表现为内衬宫颈内膜、肠和子宫内膜样上皮的非典型、不规则腺体。这些患者发生阴道非透明细胞腺癌可能与子宫内DES暴露有关。对DES暴露女性进行长期监测可能是必要的。
