Folkard M, Prise K M, Vojnovic B, Davies S, Roper M J, Michael B D
Cancer Research Campaign, Gray Laboratory, Mount Vernon Hospital, Northwood, Middlesex, U.K.
Int J Radiat Biol. 1989 Sep;56(3):221-37. doi: 10.1080/09553008914551401.
The relative biological effectiveness (RBE) has been determined for protons with mean energies of 1.9, 1.15 and 0.76 MeV, from measurements of the survival of V79 Chinese hamster cells. The cells are supported as a monolayer and are swept through a beam of scattered protons produced using a 4 MeV Van de Graaff accelerator. An estimation of the dose and unrestricted linear energy transfer (LET) variation within the sensitive volume of the cells is given for the three proton energies. The RBEs for cell survival (relative to 250 kVp X-rays) at the 10 per cent survival level are 1.6, 1.9 and 3.36 for protons with track-average LETs of 17, 24 and 32 keV microns-1 respectively, and the data suggest that protons are most effective at about 40-50 keV microns-1. It is shown that the proton RBEs can be reconciled with those of other light ions if plotted against z2/beta 2 (where z is the effective charge and beta is the relative velocity) rather than against LET.
通过对V79中国仓鼠细胞存活情况的测量，已确定了平均能量为1.9、1.15和0.76 MeV的质子的相对生物效能（RBE）。细胞以单层形式培养，并通过使用4 MeV范德格拉夫加速器产生的散射质子束进行扫描。给出了三种质子能量下细胞敏感体积内剂量和无限制线能量转移（LET）变化的估计值。在10%存活水平下，轨道平均LET分别为17、24和32 keV·μm⁻¹的质子的细胞存活RBE（相对于250 kVp X射线）分别为1.6、1.9和3.36，数据表明质子在约40 - 50 keV·μm⁻¹时最有效。结果表明，如果将质子RBE与z²/β²（其中z是有效电荷，β是相对速度）作图，而不是与LET作图，那么质子RBE可以与其他轻离子的RBE相协调。
