Fowler J F, Whitsed C A, Joiner M C
Gray Laboratory of Cancer Research Campaign, Mount Vernon Hospital, Northwood, Middlesex, U.K.
Int J Radiat Biol. 1989 Sep;56(3):335-53. doi: 10.1080/09553008914551501.
Four experiments to measure the half-time of repair of radiation damage in mouse lung are described. Three of these experiments used two or four doses per fraction of 3.6-9 Gy. Half-times of approximately 0.6 h were found. The fourth experiment investigated repair between the two doses in pairs of small doses given daily (26F x 1.1 Gy in 13 days). Evidence was obtained of more rapid repair between these small fractions, with a half-time of 0.30 h. Using the best methods of analysis appropriate to each experiment, the 95 per cent confidence limits for the T1/2 values at 1.1 Gy per fraction did not overlap with those for the large doses per fraction.
本文描述了四项测量小鼠肺部辐射损伤修复半衰期的实验。其中三项实验采用每分次2或4剂，剂量为3.6 - 9 Gy，发现半衰期约为0.6小时。第四项实验研究了每日给予的小剂量对（13天内26次，每次1.1 Gy）之间两次剂量的修复情况。有证据表明这些小分次之间的修复更快，半衰期为0.30小时。使用适合每个实验的最佳分析方法，每分次1.1 Gy时T1/2值的95%置信区间与每分次大剂量时的置信区间不重叠。
