Vegesna V, Withers H R, Taylor J M
Department of Radiation Oncology, UCLA 90024.
Radiother Oncol. 1989 May;15(1):115-23. doi: 10.1016/0167-8140(89)90124-2.
Pathological manifestations of lung damage after irradiation support the use of death between 11 weeks (80 days) and 23 weeks (160 days) as an assay for pneumonitis in the C3Hf strain of mice. The proportion of deaths and the time to reach a specific percent of lethality were found to be dose and dose per fraction-related. The median survival time and the latency period for the time of occurrence of pneumonitis, were dependent on total biological dose over a narrow range, equivalent to "normalized" doses of 36-41 Gy in 2 Gy fractions. All these criteria entered into the analysis of data. The linear-quadratic isoeffect model gives a good fit for the results over a range of doses from 1.6 to 8 Gy per fraction, that is, with the exclusion of the single dose data. The value of alpha/beta was always approximately 4.0 Gy from three kinds of analyses. The half-time for repair from sublethal injury was approximately 0.75 h. Both of these values are in agreement with the results from other investigators.
照射后肺损伤的病理表现支持将11周（80天）至23周（160天）之间的死亡作为C3Hf品系小鼠肺炎的一种检测方法。发现死亡比例和达到特定致死百分比的时间与剂量及分次剂量相关。肺炎发生时间的中位生存时间和潜伏期在狭窄范围内取决于总生物剂量，相当于2 Gy分次照射时“归一化”剂量为36 - 41 Gy。所有这些标准都纳入了数据分析。线性二次等效效应模型在每分次1.6至8 Gy的剂量范围内对结果拟合良好，即排除了单次剂量数据。通过三种分析，α/β值始终约为4.0 Gy。亚致死损伤修复的半衰期约为0.75小时。这两个值均与其他研究者的结果一致。
