Doulami Georgia, Triantafyllou Stamatina, Natoudi Maria, Albanopoulos Konstantinos, Leandros Emmanouil, Zografos Georgios, Theodorou Dimitrios
"Hippokration" General Hospital of Athens, 114 Vas Sofias Av, 11527, Athens, Greece,
Obes Surg. 2015 Oct;25(10):1882-5. doi: 10.1007/s11695-015-1614-x.
There is a strong association between obesity and gastroesophageal reflux disease (GERD). GERD-related questionnaires have been developed in order to objectify symptoms. However, none of them has been tested in obese population.
The purpose of this study is to evaluate if GERD score and GERD-Health-Related Quality of Life (HRQL) can reflect severity of the disease and screen obese patients for GERD preoperatively. GERD's impact on the quality of life of obese patients is being assessed with the use of EORTC-QLQ C30.
PATIENTS-METHODS: Obese patients during their preoperative evaluation were recruited regardless of the presence of GERD symptoms. A targeted GERD symptom history was obtained. Patients completed GERD score, GERD-HRQL, and EORTC-QLQ C30, and then, a 24-h multichannel intraluminal impedance pHmetry (MIIpH) was conducted.
Forty-seven consecutive obese patients with mean age 39.91 years and mean BMI 46.94 kg/m(2) were included in the study. GERD score and GERD-HRQL have a positive linear correlation with DeMeester score (p = 0.001 and p < 0.001, respectively). EORTC QLQ-C30 does not correlate with DeMeester score.
GERD-related questionnaires could be used in obese population as preoperative screening tool for GERD. However, our results indicate that the quality of life of obese patients is not affected by the existence of GERD.
肥胖与胃食管反流病（GERD）之间存在密切关联。为了使症状客观化，已开发出与GERD相关的问卷。然而，这些问卷均未在肥胖人群中进行过测试。
本研究的目的是评估GERD评分和GERD健康相关生活质量（HRQL）是否能够反映疾病的严重程度，并在术前对肥胖患者进行GERD筛查。使用欧洲癌症研究与治疗组织生活质量问卷C30（EORTC-QLQ C30）评估GERD对肥胖患者生活质量的影响。
在术前评估期间招募肥胖患者，无论其是否存在GERD症状。获取针对性的GERD症状病史。患者完成GERD评分、GERD-HRQL和EORTC-QLQ C30，然后进行24小时多通道腔内阻抗pH监测（MIIpH）。
本研究纳入了47例连续的肥胖患者，平均年龄39.91岁，平均体重指数（BMI）为46.94kg/m²。GERD评分和GERD-HRQL与DeMeester评分呈正线性相关（分别为p = 0.001和p < 0.001）。EORTC QLQ-C30与DeMeester评分无相关性。
与GERD相关的问卷可用于肥胖人群，作为GERD的术前筛查工具。然而，我们的结果表明，GERD的存在并不影响肥胖患者的生活质量。
