羟胺可使灌注大鼠肾脏和肠系膜的阻力血管扩张。

Hydroxylamine dilates resistance blood vessels of the perfused rat kidney and mesentery.

作者信息

Moore P K, Burrows L, Bhardwaj R

机构信息

Biomedical Sciences Division, King's College, University of London, UK.

出版信息

J Pharm Pharmacol. 1989 Jun;41(6):426-9. doi: 10.1111/j.2042-7158.1989.tb06494.x.

DOI:10.1111/j.2042-7158.1989.tb06494.x

PMID:2570844

Abstract

Hydroxylamine (ED50 values, 47 +/- 8.9 nmol and 320 +/- 39 nmol) dilates resistance arterioles of the perfused noradrenaline-preconstricted rat kidney and mesentery. In this respect hydroxylamine was approximately 63x and 320x less potent than acetylcholine (ACh) and 15x and 128x less potent than nitroprusside in the two perfused organs studied. The vasodilator effect of hydroxylamine (unlike that of ACh) was unaffected by CHAPS de-endothelialization suggesting that its effect is independent of endothelium-derived relaxing factor (EDRF).

摘要

羟胺（半数有效剂量值分别为47±8.9纳摩尔和320±39纳摩尔）可使灌注了去甲肾上腺素预收缩的大鼠肾脏和肠系膜的阻力小动脉扩张。在这方面，在所研究的两个灌注器官中，羟胺的效力分别比乙酰胆碱（ACh）低约63倍和320倍，比硝普钠低15倍和128倍。羟胺的血管舒张作用（与ACh不同）不受CHAPS去内皮处理的影响，这表明其作用独立于内皮衍生舒张因子（EDRF）。