与密集电离的α粒子相比，掺入DNA的125I的体内放射毒性。
In-vivo radiotoxicity of DNA-incorporated 125I compared with that of densely ionising alpha-particles.
作者信息
Rao D V, Narra V R, Howell R W, Govelitz G F, Sastry K S
机构信息
Department of Radiology, University of Medicine and Dentistry of New Jersey, Newark.
出版信息
Lancet. 1989 Sep 16;2(8664):650-3. doi: 10.1016/s0140-6736(89)90896-9.
Abstract
When the atomic nucleus of 125I decays by orbital electron capture followed by internal conversion, numerous very-low-energy electrons (Auger electrons) are emitted, so that the energy density in the immediate vicinity of the decay site is extremely high. 125I incorporated into DNA was as effective as densely ionising 5.3 MeV alpha-particles from 210Po in reducing the sperm-head population in mice. Hence the biological risks of Auger-electron emitting radionuclides widely used in biology and medicine ought to be reassessed.
摘要
当¹²⁵I的原子核通过轨道电子俘获随后进行内转换衰变时，会发射出大量极低能量的电子（俄歇电子），从而使衰变部位紧邻区域的能量密度极高。掺入DNA中的¹²⁵I在减少小鼠精子头部数量方面，与来自²¹⁰Po的密集电离5.3 MeVα粒子一样有效。因此，广泛应用于生物学和医学的发射俄歇电子的放射性核素的生物风险应该重新评估。
相似文献
1
In-vivo radiotoxicity of DNA-incorporated 125I compared with that of densely ionising alpha-particles.与密集电离的α粒子相比，掺入DNA的125I的体内放射毒性。
Lancet. 1989 Sep 16;2(8664):650-3. doi: 10.1016/s0140-6736(89)90896-9.
2
3
4
Radiotoxicity of thallium-201 in mouse testes: inadequacy of conventional dosimetry.
J Nucl Med. 1983 Feb;24(2):145-53.
5
6
Radiotoxicity of 125I-iododeoxyuridine in pre-implantation mouse embryos.125I-碘脱氧尿苷对植入前小鼠胚胎的放射毒性
Int J Radiat Biol. 1991 Sep;60(3):525-32. doi: 10.1080/09553009114552361.
7
8
9
Radioprotection by DMSO against the biological effects of incorporated radionuclides in vivo--Comparison with other radioprotectors and evidence for indirect action of Auger electrons.二甲基亚砜对体内掺入放射性核素生物效应的辐射防护作用——与其他辐射防护剂的比较及俄歇电子间接作用的证据
Acta Oncol. 1996;35(7):901-7. doi: 10.3109/02841869609104044.
引用本文的文献
1
Can Radionuclide Therapy be the Solution for Hepatitis B Virus Infection?放射性核素疗法能成为治疗乙型肝炎病毒感染的解决方案吗？
Nucl Med Mol Imaging. 2024 Aug;58(5):255-257. doi: 10.1007/s13139-024-00862-5. Epub 2024 May 29.
2
Establishment and activity of the planning and acting network for low dose radiation research in Japan (PLANET): 2016-2023.日本低剂量辐射研究计划与行动网络（PLANET）的建立与活动：2016-2023 年。
J Radiat Res. 2024 Sep 24;65(5):561-574. doi: 10.1093/jrr/rrae049.
3
Relative Biological Effectiveness of High LET Particles on the Reproductive System and Fetal Development.高传能线密度粒子对生殖系统和胎儿发育的相对生物效应
Life (Basel). 2020 Nov 20;10(11):298. doi: 10.3390/life10110298.
4
Auger electrons for cancer therapy - a review.用于癌症治疗的俄歇电子——综述
EJNMMI Radiopharm Chem. 2019 Oct 11;4(1):27. doi: 10.1186/s41181-019-0075-2.
5
Comparative gene expression analysis after exposure to 123I-iododeoxyuridine, γ- and α-radiation-potential biomarkers for the discrimination of radiation qualities.暴露于123I-碘脱氧尿苷、γ射线和α射线后基因表达的比较分析——用于区分辐射性质的潜在生物标志物
J Radiat Res. 2018 Jul 1;59(4):411-429. doi: 10.1093/jrr/rry038.
6
A model for optimizing delivery of targeted radionuclide therapies into resection cavity margins for the treatment of primary brain cancers.一种用于优化靶向放射性核素疗法向原发性脑癌切除腔边缘输送以进行治疗的模型。
Biomed Phys Eng Express. 2017 Jun;3(3). doi: 10.1088/2057-1976/aa6db9. Epub 2017 May 5.
7
Mechanisms of resistance to high and low linear energy transfer radiation in myeloid leukemia cells.髓系白血病细胞对高低线性能量转移辐射的抵抗机制。
Blood. 2012 Sep 6;120(10):2087-97. doi: 10.1182/blood-2012-01-404509. Epub 2012 Jul 24.
8
Radiolabeled cyclosaligenyl monophosphates of 5-iodo-2'-deoxyuridine, 5-iodo-3'-fluoro-2',3'-dideoxyuridine, and 3'-fluorothymidine for molecular radiotherapy of cancer: synthesis and biological evaluation.放射性标记的环沙立醇单磷酸酯 5-碘-2'-脱氧尿苷、5-碘-3'-氟-2',3'-二脱氧尿苷和 3'-氟胸苷用于癌症的分子放疗：合成与生物学评价。
J Med Chem. 2012 Mar 22;55(6):2649-71. doi: 10.1021/jm201482p. Epub 2012 Mar 8.
9
MIRD Pamphlet No. 22 (abridged): radiobiology and dosimetry of alpha-particle emitters for targeted radionuclide therapy.MIRD 简讯第 22 号（节选）：用于靶向放射性核素治疗的 α 粒子发射体的放射生物学和剂量学。
J Nucl Med. 2010 Feb;51(2):311-28. doi: 10.2967/jnumed.108.058651. Epub 2010 Jan 15.
10
Different contributions of the indirect effects of gamma-rays on the cytotoxicity in M10 and XRCC4 transfected M10 cells.γ射线的间接效应对M10细胞以及转染XRCC4的M10细胞细胞毒性的不同作用。
Radiat Environ Biophys. 2007 Aug;46(3):237-46. doi: 10.1007/s00411-007-0113-4. Epub 2007 May 4.
本文引用的文献
1
X-ray sensitivity of primary spermatocytes of the mouse.int.小鼠初级精母细胞的X射线敏感性。国际
Int J Radiat Biol Relat Stud Phys Chem Med. 1960 Apr;2:196-209. doi: 10.1080/09553006014550211.
2
Relation between x-ray sensivity and stages of the cell cycle in spermatogogonia of the mouse.
Radiat Res. 1962 Dec;17:809-38.
3
Dose-survival curves of human cells in tissue culture irradiated with alpha-, beta-, 20-kV. x- and 200-kV. x-radiation.
Nature. 1962 Mar 24;193:1153-5. doi: 10.1038/1931153a0.
4
A description of spermiogenesis in the mouse and its use in analysis of the cycle of the seminiferous epithelium and germ cell renewal.小鼠精子发生的描述及其在生精上皮周期和生殖细胞更新分析中的应用。
Am J Anat. 1956 Nov;99(3):391-413. doi: 10.1002/aja.1000990303.
5
A Monte Carlo treatment of the decay of 125I.
Radiat Res. 1981 Jul;87(1):10-23.
6
Lethality of Auger electrons from the decay of bromine-77 in the DNA of mammalian cells.溴-77衰变产生的俄歇电子对哺乳动物细胞DNA的致死性。
Radiat Res. 1982 May;90(2):362-73.
7
"Biological dosimetry" of radionuclides and radiation hazards.
J Nucl Med. 1983 Feb;24(2):160-4.
8
Radiotoxicity of thallium-201 in mouse testes: inadequacy of conventional dosimetry.
J Nucl Med. 1983 Feb;24(2):145-53.
9
Absorption of 20-eV to 50,000-eV electron beams in air and plastic.
Radiat Res. 1969 Apr;38(1):7-33.
10
Radiotoxicity of intranuclear tritium, 125 iodine and 131 iodine.细胞核内氚、125碘和131碘的放射毒性。
Radiat Res. 1971 Jul;47(1):94-101.
Zotero 插件