Department of Radiation Effects Research, Institute for Radiological Science, National Institutes for Quantum Science and Technology, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan.
Sustainable System Research Laboratory, Central Research Institute of Electric Power Industry, 1646 Abiko, Abiko, Chiba 270-1194, Japan.
J Radiat Res. 2024 Sep 24;65(5):561-574. doi: 10.1093/jrr/rrae049.
The Planning and Acting Network for Low Dose Radiation Research in Japan (PLANET) was established in 2017 in response to the need for an all-Japan network of experts. It serves as an academic platform to propose strategies and facilitate collaboration to improve quantitative estimation of health risks from ionizing radiation at low-doses and low-dose-rates. PLANET established Working Group 1 (Dose-Rate Effects in Animal Experiments) to consolidate findings from animal experiments on dose-rate effects in carcinogenesis. Considering international trends in this field as well as the situation in Japan, PLANET updated its priority research areas for Japanese low-dose radiation research in 2023 to include (i) characterization of low-dose and low-dose-rate radiation risk, (ii) factors to be considered for individualization of radiation risk, (iii) biological mechanisms of low-dose and low-dose-rate radiation effects and (iv) integration of epidemiology and biology. In this context, PLANET established Working Group 2 (Dose and Dose-Rate Mapping for Radiation Risk Studies) to identify the range of doses and dose rates at which observable effects on different endpoints have been reported; Working Group 3 (Species- and Organ-Specific Dose-Rate Effects) to consider the relevance of stem cell dynamics in radiation carcinogenesis of different species and organs; and Working Group 4 (Research Mapping for Radiation-Related Carcinogenesis) to sort out relevant studies, including those on non-mutagenic effects, and to identify priority research areas. These PLANET activities will be used to improve the risk assessment and to contribute to the revision of the next main recommendations of the International Commission on Radiological Protection.
日本低剂量辐射研究计划与行动网络（PLANET）于 2017 年成立，旨在建立一个全日本专家网络。它作为一个学术平台，提出策略并促进合作，以提高对低剂量和低剂量率电离辐射健康风险的定量估计。PLANET 成立了工作组 1（动物实验中的剂量率效应），以整合致癌作用中动物实验的剂量率效应研究结果。考虑到该领域的国际趋势以及日本的情况，PLANET 于 2023 年更新了日本低剂量辐射研究的优先研究领域，包括 (i) 低剂量和低剂量率辐射风险特征，(ii) 辐射风险个体化考虑因素，(iii) 低剂量和低剂量率辐射效应的生物学机制，以及 (iv) 流行病学和生物学的整合。在此背景下，PLANET 成立了工作组 2（辐射风险研究的剂量和剂量率映射），以确定不同终点观察到效应的剂量和剂量率范围；工作组 3（物种和器官特异性剂量率效应），以考虑不同物种和器官辐射致癌中干细胞动力学的相关性；工作组 4（辐射致癌相关研究映射），以整理相关研究，包括非致突变效应，并确定优先研究领域。这些 PLANET 活动将用于改进风险评估，并为国际放射防护委员会下一次主要建议的修订做出贡献。
