Mazzilli Rossella, Imbrogno Norina, Elia Jlenia, Delfino Michele, Bitterman Olimpia, Napoli Angela, Mazzilli Fernando
Department of Clinical and Molecular Medicine, Sant'Andrea Hospital, Unit of Diabetology and Endocrinology, University of Rome Sapienza, Rome, Italy.
Diabetes Metab Syndr Obes. 2015 Feb 11;8:97-101. doi: 10.2147/DMSO.S71376. eCollection 2015.
The aim of this work was to evaluate the impact of diabetes on female sexuality and to highlight any differences between sexuality in the context of type 1 and type 2 diabetes mellitus (DM).
The subjects selected were 49 women with type 1 DM, 24 women with type 2 DM, and 45 healthy women as controls. Each participant was given the nine-item Female Sexual Function Index questionnaire to complete. The metabolic profile was evaluated by body mass index and glycosylated hemoglobin assay.
The prevalence of sexual dysfunction (total score ≤30) was significantly higher in the type 1 DM group (25/49, 51%; 95% confidence interval [CI] 18-31) than in the control group (4/45, 9%; 95% CI 3-5; P=0.00006); there were no significant variations in the type 2 DM group (4/24, 17%; 95% CI 3-4) versus the control group (P=0.630, not statistically significant). The mean total score was significantly lower in the type 1 DM group (30.2±6.9) versus the control group (36.5±4.9; P=0.0003), but there was no significant difference between the type 2 DM group and the control group (P=0.773). With regard to specific questionnaire items, the mean values for arousal, lubrication, dyspareunia, and orgasm were significantly lower only in the type 1 DM group versus the control group. The mean values for desire were reduced in type 1 and type 2 DM groups versus control group.
Type 1 DM is associated with sexual dysfunction. This may be due to classic neurovascular complications or to the negative impact of the disease on psychosocial factors. Larger and ideally longitudinal studies are necessary to better understand the relationship between DM and sexual dysfunction.
本研究旨在评估糖尿病对女性性功能的影响，并突出1型和2型糖尿病（DM）患者性功能的差异。
选取49例1型糖尿病女性患者、24例2型糖尿病女性患者以及45例健康女性作为对照。每位参与者均需完成包含9个条目的女性性功能指数问卷。通过体重指数和糖化血红蛋白检测评估代谢状况。
1型糖尿病组性功能障碍（总分≤30）的患病率（25/49，51%；95%置信区间[CI] 18 - 31）显著高于对照组（4/45，9%；95% CI 3 - 5；P = 0.00006）；2型糖尿病组（4/24，17%；95% CI 3 - 4）与对照组相比无显著差异（P = 0.630，无统计学意义）。1型糖尿病组的平均总分（30.2±6.9）显著低于对照组（36.5±4.9；P = 0.0003），但2型糖尿病组与对照组之间无显著差异（P = 0.773）。关于特定问卷条目，仅1型糖尿病组与对照组相比，性唤起、润滑、性交疼痛和性高潮的平均值显著较低。1型和2型糖尿病组与对照组相比，性欲平均值降低。
1型糖尿病与性功能障碍相关。这可能归因于典型的神经血管并发症或该疾病对心理社会因素的负面影响。需要开展更大规模且理想情况下为纵向研究，以更好地理解糖尿病与性功能障碍之间的关系。
