注射用于改善颧骨后羟基磷灰石钙的完全生物可降解性：一项MRI研究

BACKGROUND

Radiesse(®) (Calcium hydroxylapatite [CaHA]) is a biocompatible, injectable gel for facial soft tissue augmentation. It is a completely biodegradable filler and this is well documented, but objective imaging methods to confirm this property are scarce.

METHODS

We present a case report in which CaHA was injected into the midface of a 50-year-old woman for volume restoration and shaping of the cheek region. On the right side of the face, 1.6 mL CaHA was injected as several (5-7) small depots (0.1-0.2 mL) using a 28G 3/4 inch needle and the vertical supraperiosteal depot technique. On the contralateral side of the face, the subject received 1.6 mL CaHA over three entry points using a 27G 1 1/2 inch blunt cannula and the fanning technique. CaHA location and degradation were assessed using magnetic resonance imaging (MRI).

RESULTS

CaHA appears as low-to-intermediate signal intensity on MRI images taken immediately after injection for malar enhancement with a symmetrical distribution. On MRI images taken 2.5 years after injection, no CaHA was visible but tissue volume remained increased, indicating a collagen-stimulating effect. The treatment was well tolerated.

CONCLUSION

In addition to producing long-lasting aesthetic and collagen-stimulating effects, MRI images confirm that CaHA is completely biodegradable with no product remaining 2.5 years after injection.

背景

瑞蓝（®）（羟基磷灰石钙[CaHA]）是一种用于面部软组织填充的生物相容性可注射凝胶。它是一种完全可生物降解的填充剂，这一点已有充分记录，但用于证实这一特性的客观成像方法却很稀少。

方法

我们报告一例病例，将CaHA注射到一名50岁女性的中面部，以恢复面部容量并塑造脸颊区域。在面部右侧，使用28G 3/4英寸针头和垂直骨膜上注射技术，以几个（5 - 7个）小剂量（0.1 - 0.2 mL）注射1.6 mL CaHA。在面部对侧，受试者使用27G 1 1/2英寸钝头套管针和扇形技术，通过三个进针点注射1.6 mL CaHA。使用磁共振成像（MRI）评估CaHA的位置和降解情况。