子痫前期孕妇与正常孕妇中选定血栓形成因子的评估。

Evaluation of selected thrombotic factors among pregnant women with preeclampsia and normal pregnant women.

作者信息

Saghafi Nafiseh, Mohammadzadeh Vatanchi Atieh, Tara Fatemeh, Pourali Leila, Dadgar Salmeh

机构信息

Department of Obstetrics and Gynecology, Qaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.

Department of Obstetrics and Gynecology, Mashhad University of Medical Sciences, Mashhad, Iran.

出版信息

Iran J Reprod Med. 2014 Dec;12(12):793-8.

PMID:25709635

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4330659/

Abstract

BACKGROUND

Preeclampsia is one of the common complications during pregnancy with considerable maternal and fetal mortality and morbidity. Hypercoagulability due to thrombophilic factors is discussed as the etiology involved in this disease.

OBJECTIVE

The aim of this study was to evaluate selected thrombotic factors among pregnant women with preeclampsia and normal pregnant women.

MATERIALS AND METHODS

This case-control study was performed on 200 pregnant women at third trimester of pregnancy between 2012 and 2013. 100 pregnant women admitted to Qaem and Imam Reza hospitals of Mashhad, due to preeclampsia, were selected as case group and 100 pregnant women without preeclampsia referred to OB/GYN clinic of these hospitals as control group. Blood samples were taken from two groups for evaluation of the coagulation factors including factor V Leiden, protein C, protein S, antithrombin III, anti-cardiolipin antibodies, and lupus anticoagulant antibodies.

RESULTS

Two groups were not significantly different in terms of maternal age and parity (p>0.05). Levels of factor V Leiden, protein C, protein S, antithrombin III, anti-cardiolipin antibodies and lupus anticoagulant antibodies were compared between two groups. The number of patients with abnormal factor V Leiden and protein C was significantly higher in case group than in the control group (p<0.01 respectively), but other factors were not significant different between two groups. Thrombophilia disorders were significantly more in case group compared to control (p<0.001).

CONCLUSION

The risk of thrombophilia disorders is higher in preeclamptic patients than normal pregnant women.

摘要

背景

子痫前期是孕期常见并发症之一，可导致相当高的母婴死亡率和发病率。因血栓形成倾向因素导致的高凝状态被认为是该病的病因之一。

目的

本研究旨在评估子痫前期孕妇和正常孕妇中选定的血栓形成因素。

材料与方法

本病例对照研究于2012年至2013年对200名孕晚期孕妇进行。将因子痫前期入住马什哈德卡姆医院和伊玛目礼萨医院的100名孕妇选为病例组，将前往这些医院妇产科门诊的100名无子痫前期孕妇作为对照组。采集两组血液样本，以评估凝血因子，包括凝血因子V莱顿突变、蛋白C、蛋白S、抗凝血酶III、抗心磷脂抗体和狼疮抗凝抗体。

结果

两组孕妇在年龄和产次方面无显著差异（p>0.05）。比较两组凝血因子V莱顿突变、蛋白C、蛋白S、抗凝血酶III、抗心磷脂抗体和狼疮抗凝抗体水平。病例组中凝血因子V莱顿突变和蛋白C异常的患者数量显著高于对照组（分别为p<0.01），但其他因素在两组间无显著差异。病例组血栓形成倾向疾病明显多于对照组（p<0.001）。