Azami Milad, Azadi Tayebe, Farhang Sepidezahra, Rahmati Shoobo, Pourtaghi Khadijeh
Student Research Committee, Ilam University of Medical Sciences, Ilam, Iran.
Nursing and Midwifery Faculty, Ilam University of Medical Sciences, Ilam, Iran.
Int J Reprod Biomed. 2017 May;15(5):273-278.
Several studies have reported the uncertain role of multi-minerals and vitamins in the prevention of preeclampsia.
The present study aims to investigate the effect of multimineral-vitamin D supplements (calcium, magnesium, zinc and Vitamin D) and vitamins (C+ E) in the prevention of preeclampsia.
In this randomized clinical trial, 90 pregnant women were divided into three groups: group A received Ferrous sulfate (1 tablet/day) + one tablet of Claci-care multimineral-vitamin D containing 800mg calcium, 200mg magnesium, 8mg zinc and 400 IU Vitamin D3 per day; group B received Ferrous sulfate (1 tablet/day) + 250 mg vitamin C + 55 mg vitamin E; and the controls received only one Ferrous sulfate tablet daily.
The incidence of preeclampsia in group A was significantly lower than the control group (p=0.03), while there was no significant difference between group B and controls (p=0.50), as well as groups A and B (p=0.063). The incidence of neonatal complications in the group A was significantly lower than the control group (p=0.01), while there was no significant difference between group B and control (p=0.48).
According to the results, calcium, magnesium, and zinc supplements have a significant effect on the prevention of preeclampsia. In addition, prescription of multimineral-vitamin D during pregnancy can be a low-cost and affordable way to reduce the incidence of preeclampsia in women who are at high risk of preeclampsia.
多项研究报告了多种矿物质和维生素在预防子痫前期中的作用尚不明确。
本研究旨在探讨多种矿物质 - 维生素D补充剂（钙、镁、锌和维生素D）以及维生素（C + E）在预防子痫前期中的作用。
在这项随机临床试验中，90名孕妇被分为三组：A组每天服用硫酸亚铁（1片）+ 1片含800毫克钙、200毫克镁、8毫克锌和400国际单位维生素D3的Claci - care多种矿物质 - 维生素D片；B组每天服用硫酸亚铁（1片）+ 250毫克维生素C + 55毫克维生素E；对照组每天仅服用1片硫酸亚铁片。
A组子痫前期的发生率显著低于对照组（p = 0.03），而B组与对照组之间（p = 0.50）以及A组和B组之间（p = 0.063）无显著差异。A组新生儿并发症的发生率显著低于对照组（p = 0.01），而B组与对照组之间无显著差异（p = 0.48）。
根据研究结果，补充钙、镁和锌对预防子痫前期有显著作用。此外，孕期服用多种矿物质 - 维生素D可能是一种低成本且可行的方法，可降低子痫前期高危女性子痫前期的发生率。
