Kumaran Arjunan Muthu, Sundar Gangadhara, Chye Lim Thiam
Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Department of Ophthalmology, National University Hospital, National University Health System, Singapore.
Craniomaxillofac Trauma Reconstr. 2015 Mar;8(1):31-41. doi: 10.1055/s-0034-1393734. Epub 2014 Nov 25.
The aim of this article is to evaluate current literature on investigation and management of traumatic optic neuropathy (TON), propose recommendations for diagnosis and management, and explore novel future treatments. TON, though uncommon, causes substantial visual loss. Without clear guidelines, there is much ambiguity regarding its diagnosis and management. Investigation and treatment (conservative, medical, surgical, and combined) vary widely between centers. Electronic databases PubMed, MEDLINE, PROSPERO, CENTRAL, and EMBASE were searched for content that matched "Traumatic optic neuropathy." Articles with abstracts and full text available, published in the past 10 years, written English and limited to human adults, were selected. All study designs were acceptable except case reports and case series with fewer 10 patients. All abstracts were then evaluated for relevance. References of these studies were evaluated and if also relevant, included. A total of 2,686 articles were retrieved and 43 examined for relevance. Of these, 23 articles were included. TON is a clinical diagnosis. Visual-evoked potential is useful in diagnosis and prognosis. Computed tomography demonstrates canal fractures and concomitant injuries. Magnetic resonance images should be reserved for select and stable patients. Conservative treatment is appropriate in mild TON. Steroids are of questionable benefit and may be harmful. Surgery should be reserved for patients with radiological evidence of compression and individualized.
本文旨在评估目前关于创伤性视神经病变(TON)的检查与治疗的文献,提出诊断和治疗建议,并探索未来的新型治疗方法。TON虽不常见,但会导致严重的视力丧失。由于缺乏明确的指南,其诊断和治疗存在很大的不确定性。各中心在检查和治疗(保守治疗、药物治疗、手术治疗及联合治疗)方面差异很大。检索了电子数据库PubMed、MEDLINE、PROSPERO、CENTRAL和EMBASE中与“创伤性视神经病变”匹配的内容。选择过去10年发表的、有摘要和全文、用英文撰写且限于成年人群体的文章。除了病例报告和患者少于10例的病例系列外,所有研究设计均可接受。然后对所有摘要进行相关性评估。对这些研究的参考文献进行评估,若也相关则纳入。共检索到2686篇文章,其中43篇接受相关性审查。其中23篇文章被纳入。TON是一种临床诊断。视觉诱发电位对诊断和预后有用。计算机断层扫描可显示管骨折及合并损伤。磁共振成像应仅用于选定的稳定患者。轻度TON适合保守治疗。类固醇的益处存疑且可能有害。手术应仅用于有压迫影像学证据的患者,并应个体化。