Maliarchuk B A, Derenko M V, Denisova G A
Genetika. 2014 Feb;50(2):189-96.
To elucidate the effect of natural selection on the evolution of mitochondrial DNA (mtDNA) in Asiatic salamanders of the family Hynobiidae, nucleotide sequences of 12 protein-coding genes were analyzed. Using a mixed effects model of evolution, it was found that, in spite of the pronounced effect of negative selection on the mtDNA evolution in Hynobiidae (which is typical for the animals in general), two phylogenetic clusters, the West Asian one, represented by the genera Ranodon and Paradactylodon, and North Eurasian one, represented by the genus Salamandrella, were formed under the influence of episodic positive selection. Analysis of protein sequences encoded by the mitochondrial genome also supported the influence of positive selection on the evolution of Hynobiidae at some stages of their cladogenesis. It is suggested that the signatures of adaptive evolution detected in the mtDNA of Hynobiidae were determined by the complex and long-lasting history of their formation, accompanied by adaptation to the changing environment.
为阐明自然选择对隐鳃鲵科亚洲蝾螈线粒体DNA（mtDNA）进化的影响，对12个蛋白质编码基因的核苷酸序列进行了分析。使用混合进化效应模型发现，尽管负选择对隐鳃鲵科mtDNA进化有显著影响（这在一般动物中很典型），但在间歇性正选择的影响下，形成了两个系统发育簇，即以滇螈属和副趾鲵属为代表的西亚簇，以及以小鲵属为代表的北欧亚簇。对线粒体基因组编码的蛋白质序列的分析也支持正选择在隐鳃鲵科系统发育的某些阶段对其进化的影响。有人认为，在隐鳃鲵科mtDNA中检测到的适应性进化特征是由其复杂而持久的形成历史决定的，同时伴随着对不断变化的环境的适应。
