Keck P E, Cohen B M, Baldessarini R J, McElroy S L
Laboratories for Psychiatric Research, Mailman Research Center, McLean Hospital, Belmont, MA 02178.
Am J Psychiatry. 1989 Oct;146(10):1289-92. doi: 10.1176/ajp.146.10.1289.
The authors reviewed relevant studies in an attempt to define the onset and time course of antipsychotic effects of neuroleptic drugs. After excluding open trials, studies of chronically psychotic patients, and studies not using a placebo or nonneuroleptic sedative as a control, they found only five reports suitable for analysis. Among these, the degree of patients' improvement during neuroleptic treatment was similar regardless of the duration of the study. Also, in studies comparing neuroleptics with sedatives, similar improvement was observed with both treatments. Although neuroleptic drugs have been used clinically for 35 years, the timing of their specific therapeutic effects remains unclear.
作者回顾了相关研究，试图明确抗精神病药物的抗精神病作用的起效时间和时间进程。在排除开放性试验、慢性精神病患者的研究以及未使用安慰剂或非抗精神病镇静剂作为对照的研究后，他们仅发现五篇适合分析的报告。在这些报告中，无论研究持续时间长短，抗精神病药物治疗期间患者的改善程度相似。此外，在将抗精神病药物与镇静剂进行比较的研究中，两种治疗方法都观察到了相似的改善效果。尽管抗精神病药物已在临床上使用了35年，但其特定治疗效果的时间仍不清楚。
