Kayar Nezahat Arzu, Alptekin Nilgun Ozlem, Haliloglu Seyfullah
Department of Periodontology, Oral and Dental Health Center, The Ministry Health of Turkey, Antalya, Turkiye.
Department of Periodontology, Faculty of Dentistry, Baskent University, Ankara, Turkiye.
Eur J Dent. 2015 Jan-Mar;9(1):109-116. doi: 10.4103/1305-7456.149655.
The aim of this study was to evaluate interleukin (IL)-1 β and IL-1 receptor antagonist (IL-1ra) levels in gingival crevicular fluid (GCF) and serum (S) in nonsmoking women with normal birth (NB), preterm low birth weight (PLBW), and intra-uterine growth retardation (IUGR).
In this unmatched case-control study design, 64 women with NB, 45 women with PLBW, and 47 women with IUGR were recruited within 24 h delivery. Clinical periodontal parameters were recorded. IL-1 β and IL-1ra levels in GCF (pg/30 s) and serum (pg/ml) of were evaluated using commercial enzyme immunoassay and ELISA kits.
Greater pocket depth and clinical attachment loss were observed in PLBW and IUGR women than in NB women (P < 0.05). The total amounts of IL-1ra and IL-β of GCF were higher levels in NB women than PLBW and IUGR women (P < 0.05). The lowest total amount of IL-1ra of GCF was found in IUGR women (P < 0.05). The concentrations of IL-1ra in serum samples were not statistically significant for any of the study groups (P > 0.05).
It can be suggested that worse periodontal conditions and the low levels of IL-1ra in GCF may be an important factor in adverse pregnancy outcomes.
本研究旨在评估正常分娩（NB）、早产低体重（PLBW）和宫内生长受限（IUGR）的非吸烟女性龈沟液（GCF）和血清（S）中白细胞介素（IL）-1β和IL-1受体拮抗剂（IL-1ra）的水平。
在这项非匹配病例对照研究设计中，64例正常分娩女性、45例早产低体重女性和47例宫内生长受限女性在分娩后24小时内被招募。记录临床牙周参数。使用商用酶免疫测定法和ELISA试剂盒评估龈沟液（pg/30秒）和血清（pg/ml）中IL-1β和IL-1ra的水平。
与正常分娩女性相比，早产低体重和宫内生长受限女性的牙周袋深度和临床附着丧失更大（P<0.05）。正常分娩女性龈沟液中IL-1ra和IL-β的总量高于早产低体重和宫内生长受限女性（P<0.05）。宫内生长受限女性龈沟液中IL-1ra的总量最低（P<0.05）。血清样本中IL-1ra的浓度在任何研究组中均无统计学意义（P>0.05）。
可以认为，较差的牙周状况和龈沟液中IL-1ra水平低可能是不良妊娠结局的一个重要因素。
