Munteanu I, Mastalier B
Department of General Surgery, CF-2 Hospital, Bucharest, Romania.
"Carol Davila" University of Medicine and Pharmacy, Surgery Clinic No. 2, Colentina Clinical Hospital, Bucharest, Romania.
J Med Life. 2014 Oct-Dec;7(4):507-11.
The occurrence of colorectal cancer is related to the interaction that takes place at several levels between hereditary factors, environmental and individual ones. Understanding the molecular basis is important because it can identify factors that contribute to the initiation of development, maintenance of progression but also determine the response or resistance to antitumor agents. Understanding colorectal cancer at the molecular level has provided data used for genetic tests of family forms, it defined predictive markers used to select patients susceptible to certain forms of therapy and also for the development of molecular diagnostic tests to detect early non-invasive cancers.
结直肠癌的发生与遗传因素、环境因素和个体因素在多个层面的相互作用有关。了解分子基础很重要，因为它可以识别促成肿瘤发生、发展维持的因素，还能确定对抗肿瘤药物的反应或耐药性。在分子水平上了解结直肠癌提供了用于家族性结直肠癌基因检测的数据，定义了用于选择对某些治疗形式敏感的患者的预测性标志物，也为检测早期非侵袭性癌症的分子诊断测试的开发提供了依据。
