Anderson Kristin, Thompson Patricia A, Wertheim Betsy C, Martin Lorena, Komenaka Ian K, Bondy Melissa, Daneri-Navarro Adrian, Meza-Montenegro Maria Mercedes, Gutierrez-Millan Luis Enrique, Brewster Abenaa, Madlensky Lisa, Tobias Malaika, Natarajan Loki, Martínez María Elena
Moores Cancer Center, University of California San Diego, 3855 Health Sciences Dr., #0901, La Jolla, CA 92093-0901 USA.
University of Arizona, Tucson, AZ USA.
Springerplus. 2014 Dec 11;3:727. doi: 10.1186/2193-1801-3-727. eCollection 2014.
Familial breast and ovarian cancer prevalence was assessed among 1150 women of Mexican descent enrolled in a case-only, binational breast cancer study. Logistic regression was conducted to compare odds of triple negative breast cancer (TNBC) to non-TNBC according to family history of breast and breast or ovarian cancer among 914 of these women. Prevalence of breast cancer family history in a first- and first- or second-degree relative was 13.1% and 24.1%, respectively; that for breast or ovarian cancer in a first-degree relative was 14.9%. After adjustment for age and country of residence, women with a first-degree relative with breast cancer were more likely to be diagnosed with TNBC than non-TNBC (OR=1.98; 95% CI, 1.26-3.11). The odds of TNBC compared to non-TNBC were 1.93 (95% CI, 1.26-2.97) for women with a first-degree relative with breast or ovarian cancer. There were non-significant stronger associations between family history and TNBC among women diagnosed at age <50 compared to ≥50 years for breast cancer in a first-degree relative (P-interaction = 0.14) and a first- or second-degree relative (P-interaction = 0.07). Findings suggest that familial breast cancers are associated with triple negative subtype, possibly related to BRCA mutations in Hispanic/Latina women, which are strongly associated with TNBC. Family history is an important tool to identify Hispanic/Latina women who may be at increased risk of TNBC, and could benefit from prevention and early detection strategies.
在一项仅针对病例的双边乳腺癌研究中，对1150名墨西哥裔女性的家族性乳腺癌和卵巢癌患病率进行了评估。在其中914名女性中，采用逻辑回归分析，根据乳腺癌家族史以及乳腺癌或卵巢癌家族史，比较三阴性乳腺癌（TNBC）与非TNBC的患病几率。一级亲属以及一级或二级亲属中有乳腺癌家族史的患病率分别为13.1%和24.1%；一级亲属中有乳腺癌或卵巢癌家族史的患病率为14.9%。在对年龄和居住国家进行调整后，有一级亲属患乳腺癌的女性被诊断为TNBC的可能性高于非TNBC（OR=1.98；95%CI，1.26 - 3.11）。对于有一级亲属患乳腺癌或卵巢癌的女性，TNBC与非TNBC相比的患病几率为1.93（95%CI，1.26 - 2.97）。与年龄≥50岁的女性相比，年龄<50岁被诊断患有乳腺癌的女性，一级亲属（P交互作用=0.14）以及一级或二级亲属（P交互作用=0.07）的家族史与TNBC之间的关联更强，但差异无统计学意义。研究结果表明，家族性乳腺癌与三阴性亚型相关，这可能与西班牙裔/拉丁裔女性中的BRCA突变有关，而BRCA突变与TNBC密切相关。家族史是识别可能患TNBC风险增加的西班牙裔/拉丁裔女性的重要工具，这些女性可能从预防和早期检测策略中受益。
