Bidirectional transfer between kindling induced either by L-glutamate or L-aspartate and electrical stimulation in rats.

Repeated spaced injections into the amygdala (AM) of rats of a subconvulsive dose of either L-glutamate (GLU) or L-aspartate (ASP) produced progressive seizure development culminating in generalized convulsion strikingly similar to electrically kindled seizure. Both GLU- and ASP-kindled AM sites responded to electrical stimulation with very rapid development of kindled seizure. When electrically kindled AM sites received identical injections of GLU or ASP, a similar positive transfer effect was obtained. These results suggest that (1) either GLU or ASP alone can kindle the AM and (2) GLU, ASP or GLU/ASP kindling share common neurobiological mechanisms with electrical kindling.