Mori N, Wada J A, Kumashiro H
Department of Neuropsychiatry, Fukushima Medical College, Japan.
Brain Res. 1989 Sep 25;498(1):163-6. doi: 10.1016/0006-8993(89)90414-9.
Repeated spaced injections into the amygdala (AM) of rats of a subconvulsive dose of either L-glutamate (GLU) or L-aspartate (ASP) produced progressive seizure development culminating in generalized convulsion strikingly similar to electrically kindled seizure. Both GLU- and ASP-kindled AM sites responded to electrical stimulation with very rapid development of kindled seizure. When electrically kindled AM sites received identical injections of GLU or ASP, a similar positive transfer effect was obtained. These results suggest that (1) either GLU or ASP alone can kindle the AM and (2) GLU, ASP or GLU/ASP kindling share common neurobiological mechanisms with electrical kindling.
向大鼠杏仁核（AM）反复间隔注射亚惊厥剂量的L-谷氨酸（GLU）或L-天冬氨酸（ASP），会导致癫痫发作逐渐发展，最终出现全身性惊厥，这与电刺激诱发的癫痫发作极为相似。GLU和ASP诱发的杏仁核位点对电刺激的反应是癫痫发作迅速发展。当电刺激诱发的杏仁核位点接受相同的GLU或ASP注射时，会产生类似的阳性转移效应。这些结果表明：（1）单独的GLU或ASP均可点燃杏仁核；（2）GLU、ASP或GLU/ASP点燃与电刺激点燃具有共同的神经生物学机制。
