Yokoyama N, Mori N, Kumashiro H
Department of Neuropsychiatry, Fukushima Medical College, Japan.
Brain Res. 1989 Jul 17;492(1-2):158-62. doi: 10.1016/0006-8993(89)90898-6.
Repeated injection of an initially subconvulsive dose of cAMP into the rat amygdala (AM) produced progressive seizure development similar to that of electrical kindling. The chemical kindling occurred in a dose-dependent manner. Furthermore, when cAMP was combined with EDTA, a strong inhibitor of cAMP phosphodiesterase, the seizure development was remarkably facilitated. When the animals that had been chemically kindled were subjected to electrical kindling, they rapidly developed seizures. These results, together with those previously published, suggest that cAMP participates in the seizure development induced by AM kindling.
向大鼠杏仁核（AM）反复注射最初低于惊厥阈值剂量的环磷酸腺苷（cAMP）会产生类似于电刺激点燃的渐进性癫痫发作发展。化学性点燃以剂量依赖的方式发生。此外，当cAMP与环磷酸腺苷磷酸二酯酶的强效抑制剂乙二胺四乙酸（EDTA）联合使用时，癫痫发作的发展会显著加速。当对已经化学性点燃的动物进行电刺激点燃时，它们会迅速出现癫痫发作。这些结果与先前发表的结果一起表明，环磷酸腺苷参与了杏仁核点燃诱导的癫痫发作发展。
