Synthesis of orotidine by intramolecular nucleosidation.
作者信息
Kim E-K, Krishnamurthy R
机构信息
Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Rd, California.
出版信息
Chem Commun (Camb). 2015 Apr 4;51(26):5618-21. doi: 10.1039/c5cc00111k.
PMID:25714895
Abstract
An intramolecular nucleosidation approach provides easy access to orotidine in high yields. Notably, orotate itself is used as a leaving group at the anomeric position. This method has the potential for facile access to derivatives of orotidine of therapeutic interest, with implications for prebiotic formation of nucleosides.
摘要
Zotero 插件