a Institute of Immunology and Infection Research ; Ashworth Laboratories ; University of Edinburgh ; Edinburgh , UK.
Cell Cycle. 2015;14(5):705-11. doi: 10.1080/15384101.2015.1007018.
The non-receptor tyrosine phosphatase PTPN22 has a vital function in inhibiting antigen-receptor signaling in T cells, while polymorphisms in the PTPN22 gene are important risk alleles in human autoimmune diseases. We recently reported that a key physiological function of PTPN22 was to prevent naïve T cell activation and effector cell responses in response to low affinity antigens. PTPN22 also has a more general role in limiting T cell receptor-induced proliferation. Here we present new data emphasizing this dual function for PTPN22 in T cells. Furthermore, we show that T cell activation modulates the expression of PTPN22 and additional inhibitory phosphatases. We discuss the implication of these findings for our understanding of the roles of PTPN22 in regulating T cell responses and in autoimmunity.
非受体酪氨酸磷酸酶 PTPN22 在抑制 T 细胞抗原受体信号转导方面具有重要功能，而 PTPN22 基因中的多态性是人类自身免疫性疾病的重要风险等位基因。我们最近报道，PTPN22 的一个关键生理功能是防止幼稚 T 细胞在低亲和力抗原刺激下激活和效应细胞反应。PTPN22 还在限制 T 细胞受体诱导的增殖方面具有更普遍的作用。在这里，我们提供了新的数据，强调了 PTPN22 在 T 细胞中的双重功能。此外，我们还表明 T 细胞激活会调节 PTPN22 和其他抑制性磷酸酶的表达。我们讨论了这些发现对我们理解 PTPN22 在调节 T 细胞反应和自身免疫中的作用的意义。
