吸烟和不吸烟的子痫前期女性的胎盘病理学

Placental pathology in smoking and non-smoking preeclamptic women.

作者信息

Vinnars Marie Therese, Falkare Sara, Papadogiannakis Nikos, Nasiell Josefine

机构信息

a Department of Clinical Science , Intervention and Technology, Division of Obstetrics and Gynecology, CLINTEC, Karolinska Institutet , Stockholm , Sweden .

b Örnsköldsviks Hospital , Örnsköldsvik , Sweden .

出版信息

J Matern Fetal Neonatal Med. 2016 Mar;29(5):733-6. doi: 10.3109/14767058.2015.1016421. Epub 2015 Feb 26.

DOI:10.3109/14767058.2015.1016421

PMID:25716079

Abstract

OBJECTIVE

To ascertain whether the protective effect of smoking during preeclampsia (PE) can be visualized in the placenta.

METHODS

The study cohort consisted of placentas (n = 523) from pregnancies complicated by PE, delivered at Karolinska University Hospital in Stockholm during the period 2000-2009. Of the women included in the study, 488 were non-smokers and 35 were smokers at first visit to maternity care. Outcome variables were placental infarctions and decidual arteriopathy.

RESULTS

Infarctions (affecting ≥5% of the placental tissue) were found in 15.6% of the placentas from non-smokers and in 25.7% of the placentas from smokers (OR 1.88: CI 0.84-4.16, p = 0.12). Decidual arteriopathy was found in 27.5% of the placentas from non-smokers and in 40.0% of the placentas from smokers (1.76: CI 0.87-3.56, p = 0.12). When diagnosed histopathologically, placental abruption was found in 15.4% among non-smokers and in 17.1% among smokers (1.14: CI 0.46-2.84, p = 0.98). Those differences did not show any statistical significance.

CONCLUSION

No significant differences concerning placental infarctions, decidual arteriopathy or abruption were found between preeclamptic placentas from non-smokers compared to smokers.

摘要

目的

确定子痫前期（PE）期间吸烟的保护作用是否能在胎盘中显现出来。

方法

研究队列包括2000年至2009年期间在斯德哥尔摩卡罗林斯卡大学医院分娩的、合并PE的妊娠胎盘（n = 523）。在纳入研究的女性中，488名在首次就诊于产科护理时为非吸烟者，35名是吸烟者。结局变量为胎盘梗死和蜕膜动脉病。

结果

非吸烟者胎盘中有15.6%发现梗死（影响≥5%的胎盘组织），吸烟者胎盘中这一比例为25.7%（比值比1.88：可信区间0.84 - 4.16，p = 0.12）。非吸烟者胎盘中有27.5%发现蜕膜动脉病，吸烟者胎盘中这一比例为40.0%（1.76：可信区间0.87 - 3.56，p = 0.12）。经组织病理学诊断，非吸烟者中胎盘早剥的发生率为15.4%，吸烟者中为17.1%（1.14：可信区间0.46 - 2.84，p = 0.98）。这些差异均无统计学意义。